| 22/08/2021 | Away | Dele Alli | Wolverhampton Wanderers FC | 9 | 0-0 → 0-1 | 0.27 | 0.79 | 0.99 | - |
| 29/08/2021 | Home | Son Heung-min | Watford FC | 42 | 0-0 → 1-0 | 0.31 | 0.04 | 0.53 | - |
| 26/09/2021 | Away | Son Heung-min | Arsenal FC | 79 | 3-0 → 3-1 | 0.01 | 0.42 | 0.82 | Sergio Reguilón |
| 03/10/2021 | Home | Pierre Højbjerg | Aston Villa FC | 27 | 0-0 → 1-0 | 0.27 | 0.12 | 0.37 | Son Heung-min |
| 03/10/2021 | Home | Matt Targett (OG) | Aston Villa FC | 71 | 1-1 → 2-1 | 0.42 | - | - | - |
| 17/10/2021 | Away | Tanguy Ndombele | Newcastle United FC | 17 | 1-0 → 1-1 | 0.20 | 0.09 | 0.35 | Sergio Reguilón |
| 17/10/2021 | Away | Harry Kane | Newcastle United FC | 22 | 1-1 → 1-2 | 0.28 | 0.43 | 0.16 | Pierre Højbjerg |
| 17/10/2021 | Away | Son Heung-min | Newcastle United FC | 49 | 1-2 → 1-3 | 0.16 | 0.73 | 0.89 | Harry Kane |
| 21/11/2021 | Home | Pierre Højbjerg | Leeds United FC | 58 | 0-1 → 1-1 | 0.28 | 0.14 | 0.67 | Lucas Moura |
| 21/11/2021 | Home | Sergio Reguilón | Leeds United FC | 69 | 1-1 → 2-1 | 0.41 | 0.67 | 0.88 | - |
| 02/12/2021 | Home | Sergi Canós (OG) | Brentford FC | 12 | 0-0 → 1-0 | 0.26 | - | - | - |
| 02/12/2021 | Home | Son Heung-min | Brentford FC | 65 | 1-0 → 2-0 | 0.14 | 0.83 | 0.94 | Sergio Reguilón |
| 05/12/2021 | Home | Lucas Moura | Norwich City FC | 10 | 0-0 → 1-0 | 0.26 | 0.02 | 0.37 | Son Heung-min |
| 05/12/2021 | Home | Davinson Sánchez | Norwich City FC | 67 | 1-0 → 2-0 | 0.14 | 0.17 | 0.57 | - |
| 05/12/2021 | Home | Son Heung-min | Norwich City FC | 77 | 2-0 → 3-0 | 0.01 | 0.14 | 0.21 | Ben Davies |
| 19/12/2021 | Home | Harry Kane | Liverpool FC | 13 | 0-0 → 1-0 | 0.26 | 0.12 | 0.61 | Tanguy Ndombele |
| 19/12/2021 | Home | Son Heung-min | Liverpool FC | 74 | 1-2 → 2-2 | 0.31 | 0.57 | 0.15 | - |
| 26/12/2021 | Home | Harry Kane | Crystal Palace FC | 32 | 0-0 → 1-0 | 0.30 | 0.43 | 0.72 | Lucas Moura |
| 26/12/2021 | Home | Lucas Moura | Crystal Palace FC | 34 | 1-0 → 2-0 | 0.18 | 0.25 | 0.51 | Emerson |
| 26/12/2021 | Home | Son Heung-min | Crystal Palace FC | 74 | 2-0 → 3-0 | 0.02 | 0.39 | 0.67 | Lucas Moura |
| 28/12/2021 | Away | Harry Kane | Southampton FC | 41 | 1-0 → 1-1 | 0.25 | 0.79 | 0.99 | - |
| 01/01/2022 | Away | Davinson Sánchez | Watford FC | 96 | 0-0 → 0-1 | 0.65 | 0.68 | 0.84 | Son Heung-min |
| 19/01/2022 | Away | Harry Kane | Leicester City FC | 38 | 1-0 → 1-1 | 0.27 | 0.53 | 0.99 | Harry Winks |
| 19/01/2022 | Away | Steven Bergwijn | Leicester City FC | 95 | 2-1 → 2-2 | 0.33 | 0.13 | 0.68 | Matt Doherty |
| 19/01/2022 | Away | Steven Bergwijn | Leicester City FC | 97 | 2-2 → 2-3 | 0.65 | 0.26 | 0.99 | Harry Kane |
| 09/02/2022 | Home | Jan Bednarek (OG) | Southampton FC | 18 | 0-0 → 1-0 | 0.26 | - | - | - |
| 09/02/2022 | Home | Son Heung-min | Southampton FC | 70 | 1-1 → 2-1 | 0.42 | 0.54 | 0.84 | Lucas Moura |
| 19/02/2022 | Away | Dejan Kulusevski | Manchester City FC | 4 | 0-0 → 0-1 | 0.25 | 0.17 | 0.12 | Son Heung-min |
| 19/02/2022 | Away | Harry Kane | Manchester City FC | 59 | 1-1 → 1-2 | 0.36 | 0.56 | 0.95 | Son Heung-min |
| 19/02/2022 | Away | Harry Kane | Manchester City FC | 95 | 2-2 → 2-3 | 0.65 | 0.44 | 0.96 | Dejan Kulusevski |
| 26/02/2022 | Away | Matt Doherty | Leeds United FC | 10 | 0-0 → 0-1 | 0.26 | 0.28 | 0.45 | Ryan Sessegnon |
| 26/02/2022 | Away | Dejan Kulusevski | Leeds United FC | 15 | 0-1 → 0-2 | 0.18 | 0.07 | 0.19 | Matt Doherty |
| 26/02/2022 | Away | Harry Kane | Leeds United FC | 27 | 0-2 → 0-3 | 0.06 | 0.11 | 0.90 | Pierre Højbjerg |
| 26/02/2022 | Away | Son Heung-min | Leeds United FC | 85 | 0-3 → 0-4 | 0.00 | 0.42 | 0.24 | Harry Kane |
| 07/03/2022 | Home | Michael Keane (OG) | Everton FC | 14 | 0-0 → 1-0 | 0.26 | - | - | - |
| 07/03/2022 | Home | Son Heung-min | Everton FC | 17 | 1-0 → 2-0 | 0.18 | 0.12 | 0.30 | Dejan Kulusevski |
| 07/03/2022 | Home | Harry Kane | Everton FC | 37 | 2-0 → 3-0 | 0.06 | 0.48 | 0.66 | Matt Doherty |
| 07/03/2022 | Home | Sergio Reguilón | Everton FC | 46 | 3-0 → 4-0 | 0.01 | 0.44 | 0.68 | Dejan Kulusevski |
| 07/03/2022 | Home | Harry Kane | Everton FC | 55 | 4-0 → 5-0 | 0.00 | 0.18 | 0.62 | Matt Doherty |
| 12/03/2022 | Away | Harry Kane | Manchester United FC | 35 | 1-0 → 1-1 | 0.27 | 0.79 | 0.99 | - |
| 12/03/2022 | Away | Harry Maguire (OG) | Manchester United FC | 72 | 2-1 → 2-2 | 0.30 | - | - | - |
| 16/03/2022 | Away | Cristian Romero | Brighton & Hove Albion FC | 37 | 0-0 → 0-1 | 0.30 | 0.14 | 0.42 | Dejan Kulusevski |
| 16/03/2022 | Away | Harry Kane | Brighton & Hove Albion FC | 57 | 0-1 → 0-2 | 0.16 | 0.28 | 0.67 | Rodrigo Bentancur |
| 20/03/2022 | Home | Kurt Zouma (OG) | West Ham United FC | 9 | 0-0 → 1-0 | 0.27 | - | - | - |
| 20/03/2022 | Home | Son Heung-min | West Ham United FC | 24 | 1-0 → 2-0 | 0.18 | 0.15 | 0.32 | Harry Kane |
| 20/03/2022 | Home | Son Heung-min | West Ham United FC | 88 | 2-1 → 3-1 | 0.04 | 0.55 | 0.68 | Harry Kane |
| 03/04/2022 | Home | Ben Davies | Newcastle United FC | 43 | 0-1 → 1-1 | 0.26 | 0.35 | 0.70 | Son Heung-min |
| 03/04/2022 | Home | Matt Doherty | Newcastle United FC | 48 | 1-1 → 2-1 | 0.33 | 0.48 | 0.96 | Harry Kane |
| 03/04/2022 | Home | Son Heung-min | Newcastle United FC | 54 | 2-1 → 3-1 | 0.15 | 0.28 | 0.86 | Dejan Kulusevski |
| 03/04/2022 | Home | Emerson | Newcastle United FC | 63 | 3-1 → 4-1 | 0.03 | 0.55 | 0.99 | - |
| 03/04/2022 | Home | Steven Bergwijn | Newcastle United FC | 83 | 4-1 → 5-1 | 0.00 | 0.50 | 0.59 | Lucas Moura |
| 09/04/2022 | Away | Son Heung-min | Aston Villa FC | 3 | 0-0 → 0-1 | 0.23 | 0.10 | 0.17 | - |
| 09/04/2022 | Away | Dejan Kulusevski | Aston Villa FC | 50 | 0-1 → 0-2 | 0.15 | 0.05 | 0.46 | Harry Kane |
| 09/04/2022 | Away | Son Heung-min | Aston Villa FC | 66 | 0-2 → 0-3 | 0.03 | 0.56 | 0.60 | Harry Kane |
| 09/04/2022 | Away | Son Heung-min | Aston Villa FC | 71 | 0-3 → 0-4 | 0.00 | 0.12 | 0.42 | Dejan Kulusevski |
| 01/05/2022 | Home | Harry Kane | Leicester City FC | 22 | 0-0 → 1-0 | 0.28 | 0.11 | 0.28 | Son Heung-min |
| 01/05/2022 | Home | Son Heung-min | Leicester City FC | 60 | 1-0 → 2-0 | 0.16 | 0.11 | 0.36 | Dejan Kulusevski |
| 01/05/2022 | Home | Son Heung-min | Leicester City FC | 79 | 2-0 → 3-0 | 0.01 | 0.01 | 0.43 | Dejan Kulusevski |
| 07/05/2022 | Away | Son Heung-min | Liverpool FC | 56 | 0-0 → 0-1 | 0.36 | 0.57 | 0.55 | Ryan Sessegnon |
| 12/05/2022 | Home | Harry Kane | Arsenal FC | 22 | 0-0 → 1-0 | 0.28 | 0.79 | 0.99 | - |
| 12/05/2022 | Home | Harry Kane | Arsenal FC | 37 | 1-0 → 2-0 | 0.18 | 0.67 | 0.78 | Rodrigo Bentancur |
| 12/05/2022 | Home | Son Heung-min | Arsenal FC | 47 | 2-0 → 3-0 | 0.06 | 0.09 | 0.30 | - |
| 15/05/2022 | Home | Harry Kane | Burnley FC | 53 | 0-0 → 1-0 | 0.35 | 0.79 | 1.00 | - |
| 22/05/2022 | Away | Dejan Kulusevski | Norwich City FC | 16 | 0-0 → 0-1 | 0.25 | 0.18 | 0.61 | Rodrigo Bentancur |
| 22/05/2022 | Away | Harry Kane | Norwich City FC | 32 | 0-1 → 0-2 | 0.17 | 0.25 | 0.52 | Rodrigo Bentancur |
| 22/05/2022 | Away | Dejan Kulusevski | Norwich City FC | 64 | 0-2 → 0-3 | 0.03 | 0.03 | 0.63 | Harry Kane |
| 22/05/2022 | Away | Son Heung-min | Norwich City FC | 70 | 0-3 → 0-4 | 0.00 | 0.27 | 0.61 | Lucas Moura |
| 22/05/2022 | Away | Son Heung-min | Norwich City FC | 75 | 0-4 → 0-5 | 0.00 | 0.02 | 0.31 | - |