| 14/08/2021 | Away | Danny Ings | Watford FC | 97 | 3-1 → 3-2 | 0.01 | 0.79 | 0.95 | - |
| 21/08/2021 | Home | Danny Ings | Newcastle United FC | 48 | 0-0 → 1-0 | 0.33 | 0.11 | 0.49 | Tyrone Mings |
| 21/08/2021 | Home | Anwar El Ghazi | Newcastle United FC | 62 | 1-0 → 2-0 | 0.16 | 0.79 | 0.98 | - |
| 28/08/2021 | Home | Emi Buendía | Brentford FC | 13 | 0-1 → 1-1 | 0.18 | 0.15 | 0.46 | Danny Ings |
| 18/09/2021 | Home | Matty Cash | Everton FC | 66 | 0-0 → 1-0 | 0.40 | 0.13 | 0.36 | Douglas Luiz |
| 18/09/2021 | Home | Lucas Digne (OG) | Everton FC | 69 | 1-0 → 2-0 | 0.13 | - | - | - |
| 18/09/2021 | Home | Leon Bailey | Everton FC | 75 | 2-0 → 3-0 | 0.02 | 0.12 | 0.04 | Danny Ings |
| 25/09/2021 | Away | Kortney Hause | Manchester United FC | 88 | 0-0 → 0-1 | 0.60 | 0.10 | 0.44 | Douglas Luiz |
| 03/10/2021 | Away | Ollie Watkins | Tottenham Hotspur FC | 67 | 1-0 → 1-1 | 0.30 | 0.56 | 0.95 | Matt Targett |
| 16/10/2021 | Home | Danny Ings | Wolverhampton Wanderers FC | 48 | 0-0 → 1-0 | 0.33 | 0.11 | 0.66 | John McGinn |
| 16/10/2021 | Home | John McGinn | Wolverhampton Wanderers FC | 68 | 1-0 → 2-0 | 0.13 | 0.03 | 0.16 | - |
| 22/10/2021 | Away | Jacob Ramsey | Arsenal FC | 82 | 3-0 → 3-1 | 0.00 | 0.07 | 0.67 | Leon Bailey |
| 31/10/2021 | Home | Ollie Watkins | West Ham United FC | 34 | 0-1 → 1-1 | 0.27 | 0.32 | 0.52 | Emi Buendía |
| 20/11/2021 | Home | Ollie Watkins | Brighton & Hove Albion FC | 84 | 0-0 → 1-0 | 0.54 | 0.15 | 0.69 | Ashley Young |
| 20/11/2021 | Home | Tyrone Mings | Brighton & Hove Albion FC | 89 | 1-0 → 2-0 | 0.04 | 0.10 | 0.07 | - |
| 27/11/2021 | Away | Matt Targett | Crystal Palace FC | 15 | 0-0 → 0-1 | 0.24 | 0.07 | 0.05 | Ashley Young |
| 27/11/2021 | Away | John McGinn | Crystal Palace FC | 86 | 0-1 → 0-2 | 0.06 | 0.07 | 0.45 | Anwar El Ghazi |
| 01/12/2021 | Home | Ollie Watkins | Manchester City FC | 47 | 0-2 → 1-2 | 0.14 | 0.04 | 0.37 | Douglas Luiz |
| 05/12/2021 | Home | Ezri Konsa | Leicester City FC | 17 | 0-1 → 1-1 | 0.20 | 0.52 | 0.92 | Emi Buendía |
| 05/12/2021 | Home | Ezri Konsa | Leicester City FC | 54 | 1-1 → 2-1 | 0.34 | 0.09 | 0.23 | John McGinn |
| 14/12/2021 | Away | Jacob Ramsey | Norwich City FC | 34 | 0-0 → 0-1 | 0.29 | 0.16 | 0.28 | Ollie Watkins |
| 14/12/2021 | Away | Ollie Watkins | Norwich City FC | 87 | 0-1 → 0-2 | 0.05 | 0.92 | 0.96 | Carney Chukwuemeka |
| 26/12/2021 | Home | Reece James (OG) | Chelsea FC | 28 | 0-0 → 1-0 | 0.29 | - | - | - |
| 02/01/2022 | Away | Danny Ings | Brentford FC | 16 | 0-0 → 0-1 | 0.25 | 0.14 | 0.73 | Emi Buendía |
| 15/01/2022 | Home | Jacob Ramsey | Manchester United FC | 77 | 0-2 → 1-2 | 0.08 | 0.46 | 0.73 | - |
| 15/01/2022 | Home | Philippe Coutinho | Manchester United FC | 81 | 1-2 → 2-2 | 0.33 | 0.69 | 0.82 | Jacob Ramsey |
| 22/01/2022 | Away | Emi Buendía | Everton FC | 48 | 0-0 → 0-1 | 0.33 | 0.05 | 0.70 | Lucas Digne |
| 09/02/2022 | Home | Philippe Coutinho | Leeds United FC | 30 | 0-1 → 1-1 | 0.26 | 0.11 | 0.57 | Matty Cash |
| 09/02/2022 | Home | Jacob Ramsey | Leeds United FC | 38 | 1-1 → 2-1 | 0.29 | 0.47 | 0.71 | Philippe Coutinho |
| 09/02/2022 | Home | Jacob Ramsey | Leeds United FC | 43 | 2-1 → 3-1 | 0.16 | 0.33 | 0.90 | Philippe Coutinho |
| 26/02/2022 | Away | Matty Cash | Brighton & Hove Albion FC | 17 | 0-0 → 0-1 | 0.25 | 0.03 | 0.38 | - |
| 26/02/2022 | Away | Ollie Watkins | Brighton & Hove Albion FC | 68 | 0-1 → 0-2 | 0.13 | 0.47 | 0.79 | Tyrone Mings |
| 05/03/2022 | Home | Ollie Watkins | Southampton FC | 9 | 0-0 → 1-0 | 0.27 | 0.31 | 0.56 | Danny Ings |
| 05/03/2022 | Home | Douglas Luiz | Southampton FC | 44 | 1-0 → 2-0 | 0.16 | 0.55 | 0.28 | Philippe Coutinho |
| 05/03/2022 | Home | Philippe Coutinho | Southampton FC | 52 | 2-0 → 3-0 | 0.05 | 0.06 | 0.08 | Danny Ings |
| 05/03/2022 | Home | Danny Ings | Southampton FC | 54 | 3-0 → 4-0 | 0.01 | 0.18 | 0.87 | Matty Cash |
| 10/03/2022 | Away | Philippe Coutinho | Leeds United FC | 22 | 0-0 → 0-1 | 0.28 | 0.17 | 0.02 | Matty Cash |
| 10/03/2022 | Away | Matty Cash | Leeds United FC | 65 | 0-1 → 0-2 | 0.14 | 0.53 | 0.78 | Danny Ings |
| 10/03/2022 | Away | Calum Chambers | Leeds United FC | 73 | 0-2 → 0-3 | 0.02 | 0.04 | 0.70 | Tyrone Mings |
| 13/03/2022 | Away | Jacob Ramsey | West Ham United FC | 90 | 2-0 → 2-1 | 0.02 | 0.11 | 0.21 | Emi Buendía |
| 02/04/2022 | Away | Ollie Watkins | Wolverhampton Wanderers FC | 86 | 2-0 → 2-1 | 0.04 | 0.79 | 0.99 | - |
| 30/04/2022 | Home | Ollie Watkins | Norwich City FC | 41 | 0-0 → 1-0 | 0.32 | 0.08 | 0.07 | Danny Ings |
| 30/04/2022 | Home | Danny Ings | Norwich City FC | 93 | 1-0 → 2-0 | 0.02 | 0.10 | 0.32 | Emi Buendía |
| 07/05/2022 | Away | Danny Ings | Burnley FC | 7 | 0-0 → 0-1 | 0.25 | 0.39 | 0.86 | Emi Buendía |
| 07/05/2022 | Away | Emi Buendía | Burnley FC | 31 | 0-1 → 0-2 | 0.17 | 0.28 | 0.09 | Lucas Digne |
| 07/05/2022 | Away | Ollie Watkins | Burnley FC | 52 | 0-2 → 0-3 | 0.05 | 0.63 | 0.45 | John McGinn |
| 10/05/2022 | Home | Douglas Luiz | Liverpool FC | 3 | 0-0 → 1-0 | 0.23 | 0.80 | 1.00 | - |
| 15/05/2022 | Home | Ollie Watkins | Crystal Palace FC | 69 | 0-0 → 1-0 | 0.41 | 0.20 | 0.48 | Lucas Digne |
| 19/05/2022 | Home | Emi Buendía | Burnley FC | 48 | 0-1 → 1-1 | 0.26 | 0.08 | 0.09 | John McGinn |
| 22/05/2022 | Away | Matty Cash | Manchester City FC | 37 | 0-0 → 0-1 | 0.30 | 0.09 | 0.35 | Lucas Digne |
| 22/05/2022 | Away | Philippe Coutinho | Manchester City FC | 69 | 0-1 → 0-2 | 0.13 | 0.09 | 0.30 | Ollie Watkins |