| 14/08/2021 | Away | Alexis Mac Allister | Burnley FC | 78 | 1-1 → 1-2 | 0.46 | 0.19 | 0.14 | Pascal Groß |
| 21/08/2021 | Home | Shane Duffy | Watford FC | 10 | 0-0 → 1-0 | 0.26 | 0.06 | 0.15 | Pascal Groß |
| 21/08/2021 | Home | Neal Maupay | Watford FC | 41 | 1-0 → 2-0 | 0.17 | 0.42 | 0.33 | Yves Bissouma |
| 11/09/2021 | Away | Leandro Trossard | Brentford FC | 90 | 0-0 → 0-1 | 0.61 | 0.07 | 0.40 | Alexis Mac Allister |
| 19/09/2021 | Home | Neal Maupay | Leicester City FC | 35 | 0-0 → 1-0 | 0.30 | 0.79 | 0.98 | - |
| 19/09/2021 | Home | Danny Welbeck | Leicester City FC | 50 | 1-0 → 2-0 | 0.15 | 0.06 | 0.25 | Leandro Trossard |
| 27/09/2021 | Away | Neal Maupay | Crystal Palace FC | 95 | 1-0 → 1-1 | 0.33 | 0.18 | 0.21 | Joël Veltman |
| 23/10/2021 | Home | Alexis Mac Allister | Manchester City FC | 81 | 0-3 → 1-3 | 0.01 | 0.79 | 0.99 | - |
| 30/10/2021 | Away | Enock Mwepu | Liverpool FC | 41 | 2-0 → 2-1 | 0.11 | 0.02 | 0.15 | Solly March |
| 30/10/2021 | Away | Leandro Trossard | Liverpool FC | 65 | 2-1 → 2-2 | 0.28 | 0.47 | 0.94 | Adam Lallana |
| 06/11/2021 | Home | Leandro Trossard | Newcastle United FC | 24 | 0-0 → 1-0 | 0.27 | 0.79 | 0.95 | - |
| 01/12/2021 | Away | Neal Maupay | West Ham United FC | 89 | 1-0 → 1-1 | 0.33 | 0.16 | 0.44 | Tariq Lamptey |
| 04/12/2021 | Away | Neal Maupay | Southampton FC | 98 | 1-0 → 1-1 | 0.33 | 0.68 | 0.57 | Jakub Moder |
| 26/12/2021 | Home | Leandro Trossard | Brentford FC | 34 | 0-0 → 1-0 | 0.29 | 0.19 | 0.35 | Enock Mwepu |
| 26/12/2021 | Home | Neal Maupay | Brentford FC | 42 | 1-0 → 2-0 | 0.17 | 0.05 | 0.55 | Jakub Moder |
| 29/12/2021 | Away | Danny Welbeck | Chelsea FC | 91 | 1-0 → 1-1 | 0.33 | 0.07 | 0.48 | Marc Cucurella |
| 02/01/2022 | Away | Alexis Mac Allister | Everton FC | 3 | 0-0 → 0-1 | 0.23 | 0.52 | 0.93 | Neal Maupay |
| 02/01/2022 | Away | Dan Burn | Everton FC | 21 | 0-1 → 0-2 | 0.17 | 0.84 | 0.77 | Enock Mwepu |
| 02/01/2022 | Away | Alexis Mac Allister | Everton FC | 71 | 1-2 → 1-3 | 0.13 | 0.04 | 0.51 | Enock Mwepu |
| 14/01/2022 | Home | Joachim Andersen (OG) | Crystal Palace FC | 87 | 0-1 → 1-1 | 0.33 | - | - | - |
| 18/01/2022 | Home | Adam Webster | Chelsea FC | 60 | 0-1 → 1-1 | 0.29 | 0.07 | 0.11 | Alexis Mac Allister |
| 23/01/2022 | Away | Danny Welbeck | Leicester City FC | 82 | 1-0 → 1-1 | 0.32 | 0.15 | 0.42 | Neal Maupay |
| 12/02/2022 | Away | Neal Maupay | Watford FC | 44 | 0-0 → 0-1 | 0.31 | 0.22 | 0.61 | Tariq Lamptey |
| 12/02/2022 | Away | Adam Webster | Watford FC | 82 | 0-1 → 0-2 | 0.09 | 0.36 | 0.65 | - |
| 05/03/2022 | Away | Lewis Dunk | Newcastle United FC | 55 | 2-0 → 2-1 | 0.15 | 0.32 | 0.57 | Pascal Groß |
| 09/04/2022 | Away | Leandro Trossard | Arsenal FC | 28 | 0-0 → 0-1 | 0.29 | 0.26 | 0.67 | Enock Mwepu |
| 09/04/2022 | Away | Enock Mwepu | Arsenal FC | 66 | 0-1 → 0-2 | 0.14 | 0.10 | 0.38 | Moisés Caicedo |
| 16/04/2022 | Away | Leandro Trossard | Tottenham Hotspur FC | 90 | 0-0 → 0-1 | 0.61 | 0.12 | 0.70 | - |
| 24/04/2022 | Home | Danny Welbeck | Southampton FC | 2 | 0-0 → 1-0 | 0.28 | 0.84 | 0.96 | - |
| 24/04/2022 | Home | Mohammed Salisu (OG) | Southampton FC | 44 | 1-0 → 2-0 | 0.16 | - | - | - |
| 30/04/2022 | Away | Alexis Mac Allister | Wolverhampton Wanderers FC | 42 | 0-0 → 0-1 | 0.31 | 0.79 | 0.99 | - |
| 30/04/2022 | Away | Leandro Trossard | Wolverhampton Wanderers FC | 70 | 0-1 → 0-2 | 0.13 | 0.23 | 0.97 | Danny Welbeck |
| 30/04/2022 | Away | Yves Bissouma | Wolverhampton Wanderers FC | 86 | 0-2 → 0-3 | 0.00 | 0.08 | 0.17 | - |
| 07/05/2022 | Home | Moisés Caicedo | Manchester United FC | 15 | 0-0 → 1-0 | 0.24 | 0.02 | 0.22 | - |
| 07/05/2022 | Home | Marc Cucurella | Manchester United FC | 49 | 1-0 → 2-0 | 0.16 | 0.10 | 0.27 | Leandro Trossard |
| 07/05/2022 | Home | Pascal Groß | Manchester United FC | 57 | 2-0 → 3-0 | 0.04 | 0.34 | 0.86 | Leandro Trossard |
| 07/05/2022 | Home | Leandro Trossard | Manchester United FC | 60 | 3-0 → 4-0 | 0.01 | 0.84 | 1.00 | - |
| 15/05/2022 | Away | Danny Welbeck | Leeds United FC | 21 | 0-0 → 0-1 | 0.28 | 0.09 | 0.15 | Yves Bissouma |
| 22/05/2022 | Home | Joël Veltman | West Ham United FC | 50 | 0-1 → 1-1 | 0.27 | 0.09 | 0.19 | Solly March |
| 22/05/2022 | Home | Pascal Groß | West Ham United FC | 80 | 1-1 → 2-1 | 0.48 | 0.13 | 0.34 | Danny Welbeck |
| 22/05/2022 | Home | Danny Welbeck | West Ham United FC | 92 | 2-1 → 3-1 | 0.02 | 0.10 | 0.48 | Pascal Groß |