| 28/08/2021 | Away | Conor Gallagher | West Ham United FC | 70 | 2-1 → 2-2 | 0.31 | 0.09 | 0.68 | - |
| 11/09/2021 | Home | Wilfried Zaha | Tottenham Hotspur FC | 76 | 0-0 → 1-0 | 0.46 | 0.79 | 0.98 | - |
| 11/09/2021 | Home | Odsonne Édouard | Tottenham Hotspur FC | 84 | 1-0 → 2-0 | 0.07 | 0.08 | 0.50 | Wilfried Zaha |
| 11/09/2021 | Home | Odsonne Édouard | Tottenham Hotspur FC | 92 | 2-0 → 3-0 | 0.00 | 0.12 | 0.70 | Conor Gallagher |
| 27/09/2021 | Home | Wilfried Zaha | Brighton & Hove Albion FC | 47 | 0-0 → 1-0 | 0.32 | 0.79 | 0.99 | - |
| 03/10/2021 | Home | Michael Olise | Leicester City FC | 61 | 0-2 → 1-2 | 0.11 | 0.17 | 0.13 | - |
| 03/10/2021 | Home | Jeffrey Schlupp | Leicester City FC | 72 | 1-2 → 2-2 | 0.30 | 0.12 | 0.16 | - |
| 18/10/2021 | Away | Christian Benteke | Arsenal FC | 50 | 1-0 → 1-1 | 0.27 | 0.15 | 0.34 | Jordan Ayew |
| 18/10/2021 | Away | Odsonne Édouard | Arsenal FC | 73 | 1-1 → 1-2 | 0.45 | 0.17 | 0.14 | Michael Olise |
| 23/10/2021 | Home | Christian Benteke | Newcastle United FC | 56 | 0-0 → 1-0 | 0.36 | 0.20 | 0.76 | Tyrick Mitchell |
| 30/10/2021 | Away | Wilfried Zaha | Manchester City FC | 6 | 0-0 → 0-1 | 0.25 | 0.10 | 0.82 | Conor Gallagher |
| 30/10/2021 | Away | Conor Gallagher | Manchester City FC | 88 | 0-1 → 0-2 | 0.04 | 0.14 | 0.47 | Michael Olise |
| 06/11/2021 | Home | Wilfried Zaha | Wolverhampton Wanderers FC | 61 | 0-0 → 1-0 | 0.37 | 0.32 | 0.87 | James McArthur |
| 06/11/2021 | Home | Conor Gallagher | Wolverhampton Wanderers FC | 78 | 1-0 → 2-0 | 0.11 | 0.08 | 0.16 | - |
| 20/11/2021 | Away | Christian Benteke | Burnley FC | 8 | 0-0 → 0-1 | 0.26 | 0.12 | 0.43 | Joachim Andersen |
| 20/11/2021 | Away | Christian Benteke | Burnley FC | 36 | 2-1 → 2-2 | 0.28 | 0.21 | 0.39 | Conor Gallagher |
| 20/11/2021 | Away | Marc Guéhi | Burnley FC | 42 | 2-2 → 2-3 | 0.31 | 0.38 | 0.11 | - |
| 27/11/2021 | Home | Marc Guéhi | Aston Villa FC | 95 | 0-2 → 1-2 | 0.01 | 0.37 | 0.64 | Cheikhou Kouyaté |
| 12/12/2021 | Home | Conor Gallagher | Everton FC | 41 | 0-0 → 1-0 | 0.32 | 0.36 | 0.13 | Jordan Ayew |
| 12/12/2021 | Home | James Tomkins | Everton FC | 62 | 1-0 → 2-0 | 0.16 | 0.30 | 0.87 | Will Hughes |
| 12/12/2021 | Home | Conor Gallagher | Everton FC | 93 | 2-1 → 3-1 | 0.02 | 0.04 | 0.38 | - |
| 15/12/2021 | Home | Wilfried Zaha | Southampton FC | 2 | 0-0 → 1-0 | 0.28 | 0.10 | 0.12 | Odsonne Édouard |
| 15/12/2021 | Home | Jordan Ayew | Southampton FC | 65 | 1-2 → 2-2 | 0.28 | 0.19 | 0.67 | - |
| 28/12/2021 | Home | Odsonne Édouard | Norwich City FC | 8 | 0-0 → 1-0 | 0.26 | 0.79 | 0.99 | - |
| 28/12/2021 | Home | Jean-Philippe Mateta | Norwich City FC | 38 | 1-0 → 2-0 | 0.18 | 0.09 | 0.47 | Odsonne Édouard |
| 28/12/2021 | Home | Jeffrey Schlupp | Norwich City FC | 42 | 2-0 → 3-0 | 0.06 | 0.03 | 0.57 | Odsonne Édouard |
| 01/01/2022 | Home | Odsonne Édouard | West Ham United FC | 83 | 0-3 → 1-3 | 0.00 | 0.66 | 0.67 | Michael Olise |
| 01/01/2022 | Home | Michael Olise | West Ham United FC | 90 | 1-3 → 2-3 | 0.02 | 0.05 | 0.54 | - |
| 14/01/2022 | Away | Conor Gallagher | Brighton & Hove Albion FC | 69 | 0-0 → 0-1 | 0.41 | 0.14 | 0.90 | Jeffrey Schlupp |
| 23/01/2022 | Home | Odsonne Édouard | Liverpool FC | 55 | 0-2 → 1-2 | 0.15 | 0.83 | 0.23 | Jean-Philippe Mateta |
| 09/02/2022 | Away | Wilfried Zaha | Norwich City FC | 60 | 1-0 → 1-1 | 0.29 | 0.02 | 0.55 | Michael Olise |
| 23/02/2022 | Away | Jean-Philippe Mateta | Watford FC | 15 | 0-0 → 0-1 | 0.24 | 0.10 | 0.02 | - |
| 23/02/2022 | Away | Conor Gallagher | Watford FC | 42 | 1-1 → 1-2 | 0.31 | 0.52 | 0.89 | Tyrick Mitchell |
| 23/02/2022 | Away | Wilfried Zaha | Watford FC | 85 | 1-2 → 1-3 | 0.07 | 0.09 | 0.04 | Jordan Ayew |
| 23/02/2022 | Away | Wilfried Zaha | Watford FC | 90 | 1-3 → 1-4 | 0.00 | 0.10 | 0.65 | James McArthur |
| 26/02/2022 | Home | Jeffrey Schlupp | Burnley FC | 9 | 0-0 → 1-0 | 0.27 | 0.53 | 0.74 | Michael Olise |
| 05/03/2022 | Away | Jean-Philippe Mateta | Wolverhampton Wanderers FC | 19 | 0-0 → 0-1 | 0.25 | 0.97 | 0.99 | - |
| 05/03/2022 | Away | Wilfried Zaha | Wolverhampton Wanderers FC | 34 | 0-1 → 0-2 | 0.18 | 0.79 | 0.95 | - |
| 04/04/2022 | Home | Jean-Philippe Mateta | Arsenal FC | 16 | 0-0 → 1-0 | 0.25 | 0.28 | 0.03 | Joachim Andersen |
| 04/04/2022 | Home | Jordan Ayew | Arsenal FC | 24 | 1-0 → 2-0 | 0.18 | 0.24 | 0.40 | Joachim Andersen |
| 04/04/2022 | Home | Wilfried Zaha | Arsenal FC | 74 | 2-0 → 3-0 | 0.02 | 0.79 | 0.98 | - |
| 10/04/2022 | Away | Wilfried Zaha | Leicester City FC | 65 | 2-0 → 2-1 | 0.11 | 0.34 | 0.17 | - |
| 30/04/2022 | Away | Eberechi Eze | Southampton FC | 60 | 1-0 → 1-1 | 0.29 | 0.15 | 0.06 | Nathaniel Clyne |
| 30/04/2022 | Away | Wilfried Zaha | Southampton FC | 92 | 1-1 → 1-2 | 0.63 | 0.08 | 0.47 | James McArthur |
| 07/05/2022 | Home | Wilfried Zaha | Watford FC | 31 | 0-0 → 1-0 | 0.30 | 0.79 | 0.99 | - |
| 15/05/2022 | Away | Jeffrey Schlupp | Aston Villa FC | 81 | 1-0 → 1-1 | 0.33 | 0.77 | 0.93 | Marc Guéhi |
| 19/05/2022 | Away | Jean-Philippe Mateta | Everton FC | 21 | 0-0 → 0-1 | 0.28 | 0.38 | 0.17 | Eberechi Eze |
| 19/05/2022 | Away | Jordan Ayew | Everton FC | 36 | 0-1 → 0-2 | 0.18 | 0.39 | 0.77 | - |
| 22/05/2022 | Home | Wilfried Zaha | Manchester United FC | 37 | 0-0 → 1-0 | 0.30 | 0.08 | 0.50 | - |