| 23/08/2021 | Away | Youri Tielemans | West Ham United FC | 69 | 2-0 → 2-1 | 0.09 | 0.18 | 0.46 | - |
| 28/08/2021 | Away | Jamie Vardy | Norwich City FC | 8 | 0-0 → 0-1 | 0.26 | 0.37 | 0.72 | Ricardo Pereira |
| 28/08/2021 | Away | Marc Albrighton | Norwich City FC | 76 | 1-1 → 1-2 | 0.46 | 0.03 | 0.34 | Jamie Vardy |
| 19/09/2021 | Away | Jamie Vardy | Brighton & Hove Albion FC | 61 | 2-0 → 2-1 | 0.11 | 0.96 | 0.97 | Youri Tielemans |
| 25/09/2021 | Home | Jamie Vardy | Burnley FC | 37 | 0-1 → 1-1 | 0.25 | 0.13 | 0.35 | Youri Tielemans |
| 25/09/2021 | Home | Jamie Vardy | Burnley FC | 85 | 1-2 → 2-2 | 0.32 | 0.53 | 0.46 | Kelechi Iheanacho |
| 03/10/2021 | Away | Kelechi Iheanacho | Crystal Palace FC | 31 | 0-0 → 0-1 | 0.30 | 0.34 | 0.63 | - |
| 03/10/2021 | Away | Jamie Vardy | Crystal Palace FC | 37 | 0-1 → 0-2 | 0.18 | 0.37 | 0.62 | Harvey Barnes |
| 16/10/2021 | Home | Youri Tielemans | Manchester United FC | 31 | 0-1 → 1-1 | 0.24 | 0.04 | 0.71 | Kelechi Iheanacho |
| 16/10/2021 | Home | Çağlar Söyüncü | Manchester United FC | 78 | 1-1 → 2-1 | 0.46 | 0.67 | 0.38 | Ayoze Pérez |
| 16/10/2021 | Home | Jamie Vardy | Manchester United FC | 83 | 2-2 → 3-2 | 0.53 | 0.13 | 0.45 | Ayoze Pérez |
| 16/10/2021 | Home | Patson Daka | Manchester United FC | 91 | 3-2 → 4-2 | 0.03 | 0.38 | 0.94 | - |
| 24/10/2021 | Away | Youri Tielemans | Brentford FC | 14 | 0-0 → 0-1 | 0.26 | 0.01 | 0.22 | - |
| 24/10/2021 | Away | James Maddison | Brentford FC | 73 | 1-1 → 1-2 | 0.45 | 0.92 | 0.72 | Patson Daka |
| 07/11/2021 | Away | Harvey Barnes | Leeds United FC | 28 | 1-0 → 1-1 | 0.25 | 0.04 | 0.81 | Boubakary Soumaré |
| 28/11/2021 | Home | James Maddison | Watford FC | 16 | 0-0 → 1-0 | 0.25 | 0.35 | 0.65 | Jonny Evans |
| 28/11/2021 | Home | Jamie Vardy | Watford FC | 34 | 1-1 → 2-1 | 0.29 | 0.15 | 0.08 | James Maddison |
| 28/11/2021 | Home | Jamie Vardy | Watford FC | 42 | 2-1 → 3-1 | 0.17 | 0.01 | 0.25 | James Maddison |
| 28/11/2021 | Home | Ademola Lookman | Watford FC | 68 | 3-2 → 4-2 | 0.13 | 0.98 | 0.98 | - |
| 01/12/2021 | Away | Jonny Evans | Southampton FC | 22 | 1-0 → 1-1 | 0.24 | 0.23 | 0.18 | - |
| 01/12/2021 | Away | James Maddison | Southampton FC | 49 | 2-1 → 2-2 | 0.26 | 0.12 | 0.32 | Luke Thomas |
| 05/12/2021 | Away | Harvey Barnes | Aston Villa FC | 14 | 0-0 → 0-1 | 0.26 | 0.09 | 0.69 | Patson Daka |
| 12/12/2021 | Home | Youri Tielemans | Newcastle United FC | 38 | 0-0 → 1-0 | 0.29 | 0.79 | 1.00 | - |
| 12/12/2021 | Home | Patson Daka | Newcastle United FC | 57 | 1-0 → 2-0 | 0.16 | 0.97 | 0.58 | Harvey Barnes |
| 12/12/2021 | Home | Youri Tielemans | Newcastle United FC | 81 | 2-0 → 3-0 | 0.01 | 0.51 | 0.97 | James Maddison |
| 12/12/2021 | Home | James Maddison | Newcastle United FC | 85 | 3-0 → 4-0 | 0.00 | 0.07 | 0.30 | Patson Daka |
| 26/12/2021 | Away | James Maddison | Manchester City FC | 55 | 4-0 → 4-1 | 0.00 | 0.41 | 0.49 | Kelechi Iheanacho |
| 26/12/2021 | Away | Ademola Lookman | Manchester City FC | 59 | 4-1 → 4-2 | 0.00 | 0.51 | 0.71 | Kelechi Iheanacho |
| 26/12/2021 | Away | Kelechi Iheanacho | Manchester City FC | 65 | 4-2 → 4-3 | 0.11 | 0.70 | 0.99 | - |
| 28/12/2021 | Home | Ademola Lookman | Liverpool FC | 59 | 0-0 → 1-0 | 0.36 | 0.10 | 0.14 | Kiernan Dewsbury-Hall |
| 19/01/2022 | Home | Patson Daka | Tottenham Hotspur FC | 24 | 0-0 → 1-0 | 0.27 | 0.20 | 0.34 | - |
| 19/01/2022 | Home | James Maddison | Tottenham Hotspur FC | 76 | 1-1 → 2-1 | 0.46 | 0.10 | 0.72 | Harvey Barnes |
| 23/01/2022 | Home | Patson Daka | Brighton & Hove Albion FC | 46 | 0-0 → 1-0 | 0.32 | 0.28 | 0.79 | - |
| 13/02/2022 | Home | Youri Tielemans | West Ham United FC | 45 | 0-1 → 1-1 | 0.27 | 0.79 | 0.99 | - |
| 13/02/2022 | Home | Ricardo Pereira | West Ham United FC | 57 | 1-1 → 2-1 | 0.36 | 0.17 | 0.48 | Harvey Barnes |
| 20/02/2022 | Away | Ademola Lookman | Wolverhampton Wanderers FC | 41 | 1-0 → 1-1 | 0.25 | 0.93 | 0.97 | Marc Albrighton |
| 01/03/2022 | Away | James Maddison | Burnley FC | 82 | 0-0 → 0-1 | 0.52 | 0.05 | 0.33 | Jamie Vardy |
| 01/03/2022 | Away | Jamie Vardy | Burnley FC | 90 | 0-1 → 0-2 | 0.03 | 0.27 | 0.35 | Harvey Barnes |
| 05/03/2022 | Home | Harvey Barnes | Leeds United FC | 67 | 0-0 → 1-0 | 0.40 | 0.08 | 0.33 | Kelechi Iheanacho |
| 20/03/2022 | Home | Timothy Castagne | Brentford FC | 20 | 0-0 → 1-0 | 0.27 | 0.04 | 0.58 | Harvey Barnes |
| 20/03/2022 | Home | James Maddison | Brentford FC | 33 | 1-0 → 2-0 | 0.17 | 0.08 | 0.44 | - |
| 02/04/2022 | Away | Kelechi Iheanacho | Manchester United FC | 63 | 0-0 → 0-1 | 0.38 | 0.15 | 0.68 | James Maddison |
| 10/04/2022 | Home | Ademola Lookman | Crystal Palace FC | 39 | 0-0 → 1-0 | 0.31 | 0.21 | 0.15 | Kiernan Dewsbury-Hall |
| 10/04/2022 | Home | Kiernan Dewsbury-Hall | Crystal Palace FC | 45 | 1-0 → 2-0 | 0.16 | 0.05 | 0.28 | James Maddison |
| 17/04/2022 | Away | Ademola Lookman | Newcastle United FC | 19 | 0-0 → 0-1 | 0.25 | 0.14 | 0.14 | Ayoze Pérez |
| 20/04/2022 | Away | Harvey Barnes | Everton FC | 5 | 0-0 → 0-1 | 0.26 | 0.23 | 0.75 | - |
| 01/05/2022 | Away | Kelechi Iheanacho | Tottenham Hotspur FC | 91 | 3-0 → 3-1 | 0.00 | 0.04 | 0.24 | Youri Tielemans |
| 08/05/2022 | Home | Patson Daka | Everton FC | 11 | 0-1 → 1-1 | 0.25 | 0.36 | 0.44 | - |
| 11/05/2022 | Home | Jamie Vardy | Norwich City FC | 54 | 0-0 → 1-0 | 0.34 | 0.06 | 0.04 | Harvey Barnes |
| 11/05/2022 | Home | Jamie Vardy | Norwich City FC | 62 | 1-0 → 2-0 | 0.16 | 0.36 | 0.63 | Harvey Barnes |
| 11/05/2022 | Home | James Maddison | Norwich City FC | 70 | 2-0 → 3-0 | 0.03 | 0.09 | 0.12 | - |
| 15/05/2022 | Away | James Maddison | Watford FC | 18 | 1-0 → 1-1 | 0.24 | 0.44 | 0.74 | Youri Tielemans |
| 15/05/2022 | Away | Jamie Vardy | Watford FC | 22 | 1-1 → 1-2 | 0.28 | 0.35 | 0.03 | James Maddison |
| 15/05/2022 | Away | Harvey Barnes | Watford FC | 46 | 1-2 → 1-3 | 0.16 | 0.40 | 0.36 | Marc Albrighton |
| 15/05/2022 | Away | Jamie Vardy | Watford FC | 70 | 1-3 → 1-4 | 0.03 | 0.64 | 0.94 | Harvey Barnes |
| 15/05/2022 | Away | Harvey Barnes | Watford FC | 86 | 1-4 → 1-5 | 0.00 | 0.12 | 0.81 | James Maddison |
| 19/05/2022 | Away | James Maddison | Chelsea FC | 6 | 0-0 → 0-1 | 0.25 | 0.06 | 0.17 | - |
| 22/05/2022 | Home | James Maddison | Southampton FC | 49 | 0-0 → 1-0 | 0.34 | 0.81 | 0.58 | - |
| 22/05/2022 | Home | Jamie Vardy | Southampton FC | 74 | 1-0 → 2-0 | 0.12 | 0.61 | 0.97 | Harvey Barnes |
| 22/05/2022 | Home | Ayoze Pérez | Southampton FC | 81 | 2-1 → 3-1 | 0.09 | 0.40 | 0.74 | James Maddison |
| 22/05/2022 | Home | Ayoze Pérez | Southampton FC | 96 | 3-1 → 4-1 | 0.00 | 0.32 | 0.85 | Ricardo Pereira |