| 14/08/2021 | Away | Roberto Firmino | Norwich City FC | 65 | 0-1 → 0-2 | 0.14 | 0.51 | 0.32 | Mohamed Salah |
| 14/08/2021 | Away | Mohamed Salah | Norwich City FC | 74 | 0-2 → 0-3 | 0.02 | 0.05 | 0.10 | - |
| 21/08/2021 | Home | Diogo Jota | Burnley FC | 18 | 0-0 → 1-0 | 0.26 | 0.11 | 0.27 | Kostas Tsimikas |
| 21/08/2021 | Home | Sadio Mané | Burnley FC | 69 | 1-0 → 2-0 | 0.13 | 0.49 | 0.69 | Trent Alexander-Arnold |
| 28/08/2021 | Home | Mohamed Salah | Chelsea FC | 50 | 0-1 → 1-1 | 0.27 | 0.79 | 0.98 | - |
| 12/09/2021 | Away | Mohamed Salah | Leeds United FC | 20 | 0-0 → 0-1 | 0.27 | 0.64 | 0.90 | Trent Alexander-Arnold |
| 12/09/2021 | Away | Fabinho | Leeds United FC | 50 | 0-1 → 0-2 | 0.15 | 0.13 | 0.06 | - |
| 12/09/2021 | Away | Sadio Mané | Leeds United FC | 92 | 0-2 → 0-3 | 0.00 | 0.27 | 0.77 | Thiago Alcántara |
| 18/09/2021 | Home | Sadio Mané | Crystal Palace FC | 43 | 0-0 → 1-0 | 0.31 | 0.62 | 0.37 | - |
| 18/09/2021 | Home | Mohamed Salah | Crystal Palace FC | 78 | 1-0 → 2-0 | 0.11 | 0.29 | 0.36 | Virgil van Dijk |
| 18/09/2021 | Home | Naby Keïta | Crystal Palace FC | 89 | 2-0 → 3-0 | 0.00 | 0.03 | 0.44 | - |
| 25/09/2021 | Away | Diogo Jota | Brentford FC | 31 | 1-0 → 1-1 | 0.24 | 0.22 | 0.59 | Jordan Henderson |
| 25/09/2021 | Away | Mohamed Salah | Brentford FC | 54 | 1-1 → 1-2 | 0.34 | 0.46 | 0.94 | Fabinho |
| 25/09/2021 | Away | Curtis Jones | Brentford FC | 67 | 2-2 → 2-3 | 0.40 | 0.02 | 0.16 | Andrew Robertson |
| 03/10/2021 | Home | Sadio Mané | Manchester City FC | 59 | 0-0 → 1-0 | 0.36 | 0.36 | 0.83 | Mohamed Salah |
| 03/10/2021 | Home | Mohamed Salah | Manchester City FC | 76 | 1-1 → 2-1 | 0.46 | 0.14 | 0.97 | Curtis Jones |
| 16/10/2021 | Away | Sadio Mané | Watford FC | 9 | 0-0 → 0-1 | 0.27 | 0.23 | 0.67 | Mohamed Salah |
| 16/10/2021 | Away | Roberto Firmino | Watford FC | 37 | 0-1 → 0-2 | 0.18 | 0.96 | 0.86 | James Milner |
| 16/10/2021 | Away | Roberto Firmino | Watford FC | 52 | 0-2 → 0-3 | 0.05 | 0.22 | 0.92 | - |
| 16/10/2021 | Away | Mohamed Salah | Watford FC | 54 | 0-3 → 0-4 | 0.01 | 0.10 | 0.25 | Roberto Firmino |
| 16/10/2021 | Away | Roberto Firmino | Watford FC | 91 | 0-4 → 0-5 | 0.00 | 0.70 | 0.37 | Neco Williams |
| 24/10/2021 | Away | Naby Keïta | Manchester United FC | 5 | 0-0 → 0-1 | 0.26 | 0.54 | 0.60 | Mohamed Salah |
| 24/10/2021 | Away | Diogo Jota | Manchester United FC | 13 | 0-1 → 0-2 | 0.18 | 0.68 | 0.97 | Trent Alexander-Arnold |
| 24/10/2021 | Away | Mohamed Salah | Manchester United FC | 38 | 0-2 → 0-3 | 0.06 | 0.44 | 0.77 | Naby Keïta |
| 24/10/2021 | Away | Mohamed Salah | Manchester United FC | 50 | 0-3 → 0-4 | 0.01 | 0.27 | 0.82 | Diogo Jota |
| 24/10/2021 | Away | Mohamed Salah | Manchester United FC | 50 | 0-3 → 0-4 | 0.01 | 0.27 | 0.82 | Jordan Henderson |
| 30/10/2021 | Home | Jordan Henderson | Brighton & Hove Albion FC | 4 | 0-0 → 1-0 | 0.25 | 0.04 | 0.31 | Mohamed Salah |
| 30/10/2021 | Home | Sadio Mané | Brighton & Hove Albion FC | 24 | 1-0 → 2-0 | 0.18 | 0.35 | 0.67 | Alex Oxlade-Chamberlain |
| 07/11/2021 | Away | Trent Alexander-Arnold | West Ham United FC | 41 | 1-0 → 1-1 | 0.25 | 0.12 | 0.41 | Mohamed Salah |
| 07/11/2021 | Away | Divock Origi | West Ham United FC | 83 | 3-1 → 3-2 | 0.06 | 0.06 | 0.30 | Trent Alexander-Arnold |
| 20/11/2021 | Home | Sadio Mané | Arsenal FC | 39 | 0-0 → 1-0 | 0.31 | 0.21 | 0.30 | Trent Alexander-Arnold |
| 20/11/2021 | Home | Diogo Jota | Arsenal FC | 52 | 1-0 → 2-0 | 0.15 | 0.97 | 0.53 | - |
| 20/11/2021 | Home | Mohamed Salah | Arsenal FC | 73 | 2-0 → 3-0 | 0.02 | 0.79 | 0.81 | Sadio Mané |
| 20/11/2021 | Home | Takumi Minamino | Arsenal FC | 77 | 3-0 → 4-0 | 0.00 | 0.90 | 0.96 | Trent Alexander-Arnold |
| 27/11/2021 | Home | Diogo Jota | Southampton FC | 2 | 0-0 → 1-0 | 0.28 | 0.64 | 0.87 | Andrew Robertson |
| 27/11/2021 | Home | Diogo Jota | Southampton FC | 32 | 1-0 → 2-0 | 0.17 | 0.82 | 0.84 | Mohamed Salah |
| 27/11/2021 | Home | Thiago Alcántara | Southampton FC | 37 | 2-0 → 3-0 | 0.06 | 0.06 | 0.13 | - |
| 27/11/2021 | Home | Virgil van Dijk | Southampton FC | 52 | 3-0 → 4-0 | 0.01 | 0.09 | 0.05 | Trent Alexander-Arnold |
| 01/12/2021 | Away | Jordan Henderson | Everton FC | 9 | 0-0 → 0-1 | 0.27 | 0.09 | 0.33 | Andrew Robertson |
| 01/12/2021 | Away | Mohamed Salah | Everton FC | 19 | 0-1 → 0-2 | 0.17 | 0.31 | 0.96 | Jordan Henderson |
| 01/12/2021 | Away | Mohamed Salah | Everton FC | 64 | 1-2 → 1-3 | 0.15 | 0.25 | 0.96 | - |
| 01/12/2021 | Away | Diogo Jota | Everton FC | 79 | 1-3 → 1-4 | 0.01 | 0.16 | 0.47 | Andrew Robertson |
| 04/12/2021 | Away | Divock Origi | Wolverhampton Wanderers FC | 94 | 0-0 → 0-1 | 0.64 | 0.33 | 0.81 | Mohamed Salah |
| 11/12/2021 | Home | Mohamed Salah | Aston Villa FC | 67 | 0-0 → 1-0 | 0.40 | 0.79 | 1.00 | - |
| 16/12/2021 | Home | Diogo Jota | Newcastle United FC | 21 | 0-1 → 1-1 | 0.26 | 0.80 | 0.86 | - |
| 16/12/2021 | Home | Mohamed Salah | Newcastle United FC | 25 | 1-1 → 2-1 | 0.27 | 0.37 | 0.57 | - |
| 16/12/2021 | Home | Trent Alexander-Arnold | Newcastle United FC | 87 | 2-1 → 3-1 | 0.05 | 0.02 | 0.23 | Roberto Firmino |
| 19/12/2021 | Away | Diogo Jota | Tottenham Hotspur FC | 35 | 1-0 → 1-1 | 0.27 | 0.12 | 0.31 | Andrew Robertson |
| 19/12/2021 | Away | Andrew Robertson | Tottenham Hotspur FC | 69 | 1-1 → 1-2 | 0.41 | 0.34 | 0.92 | Trent Alexander-Arnold |
| 02/01/2022 | Away | Sadio Mané | Chelsea FC | 9 | 0-0 → 0-1 | 0.27 | 0.51 | 0.36 | - |
| 02/01/2022 | Away | Mohamed Salah | Chelsea FC | 26 | 0-1 → 0-2 | 0.18 | 0.17 | 0.22 | Trent Alexander-Arnold |
| 16/01/2022 | Home | Fabinho | Brentford FC | 44 | 0-0 → 1-0 | 0.31 | 0.20 | 0.63 | Trent Alexander-Arnold |
| 16/01/2022 | Home | Alex Oxlade-Chamberlain | Brentford FC | 69 | 1-0 → 2-0 | 0.13 | 0.16 | 0.35 | Andrew Robertson |
| 16/01/2022 | Home | Takumi Minamino | Brentford FC | 77 | 2-0 → 3-0 | 0.01 | 0.37 | 0.83 | Roberto Firmino |
| 23/01/2022 | Away | Virgil van Dijk | Crystal Palace FC | 8 | 0-0 → 0-1 | 0.26 | 0.08 | 0.32 | Andrew Robertson |
| 23/01/2022 | Away | Alex Oxlade-Chamberlain | Crystal Palace FC | 32 | 0-1 → 0-2 | 0.17 | 0.41 | 0.03 | Andrew Robertson |
| 23/01/2022 | Away | Fabinho | Crystal Palace FC | 89 | 1-2 → 1-3 | 0.04 | 0.79 | 0.99 | - |
| 10/02/2022 | Home | Diogo Jota | Leicester City FC | 34 | 0-0 → 1-0 | 0.29 | 0.42 | 0.37 | - |
| 10/02/2022 | Home | Diogo Jota | Leicester City FC | 87 | 1-0 → 2-0 | 0.05 | 0.10 | 0.71 | Joël Matip |
| 13/02/2022 | Away | Fabinho | Burnley FC | 40 | 0-0 → 0-1 | 0.31 | 0.59 | 0.99 | - |
| 19/02/2022 | Home | Sadio Mané | Norwich City FC | 64 | 0-1 → 1-1 | 0.29 | 0.52 | 0.47 | Kostas Tsimikas |
| 19/02/2022 | Home | Mohamed Salah | Norwich City FC | 67 | 1-1 → 2-1 | 0.40 | 0.23 | 0.61 | Alisson |
| 19/02/2022 | Home | Luis Díaz | Norwich City FC | 81 | 2-1 → 3-1 | 0.09 | 0.44 | 0.89 | Jordan Henderson |
| 23/02/2022 | Home | Mohamed Salah | Leeds United FC | 15 | 0-0 → 1-0 | 0.24 | 0.79 | 1.00 | - |
| 23/02/2022 | Home | Joël Matip | Leeds United FC | 30 | 1-0 → 2-0 | 0.17 | 0.45 | 0.42 | Mohamed Salah |
| 23/02/2022 | Home | Mohamed Salah | Leeds United FC | 35 | 2-0 → 3-0 | 0.06 | 0.79 | 0.99 | - |
| 23/02/2022 | Home | Sadio Mané | Leeds United FC | 80 | 3-0 → 4-0 | 0.00 | 0.54 | 0.47 | Jordan Henderson |
| 23/02/2022 | Home | Sadio Mané | Leeds United FC | 90 | 4-0 → 5-0 | 0.00 | 0.97 | 0.78 | - |
| 23/02/2022 | Home | Virgil van Dijk | Leeds United FC | 93 | 5-0 → 6-0 | 0.00 | 0.26 | 0.29 | Andrew Robertson |
| 05/03/2022 | Home | Sadio Mané | West Ham United FC | 27 | 0-0 → 1-0 | 0.27 | 0.85 | 0.94 | Trent Alexander-Arnold |
| 12/03/2022 | Away | Luis Díaz | Brighton & Hove Albion FC | 19 | 0-0 → 0-1 | 0.25 | 0.14 | 0.47 | Joël Matip |
| 12/03/2022 | Away | Mohamed Salah | Brighton & Hove Albion FC | 61 | 0-1 → 0-2 | 0.16 | 0.79 | 0.88 | - |
| 16/03/2022 | Away | Diogo Jota | Arsenal FC | 54 | 0-0 → 0-1 | 0.34 | 0.04 | 0.12 | Thiago Alcántara |
| 16/03/2022 | Away | Roberto Firmino | Arsenal FC | 62 | 0-1 → 0-2 | 0.16 | 0.30 | 0.87 | Andrew Robertson |
| 02/04/2022 | Home | Diogo Jota | Watford FC | 22 | 0-0 → 1-0 | 0.28 | 0.54 | 0.93 | Joe Gomez |
| 02/04/2022 | Home | Fabinho | Watford FC | 89 | 1-0 → 2-0 | 0.04 | 0.79 | 1.00 | - |
| 10/04/2022 | Away | Diogo Jota | Manchester City FC | 13 | 1-0 → 1-1 | 0.18 | 0.35 | 0.95 | Trent Alexander-Arnold |
| 10/04/2022 | Away | Sadio Mané | Manchester City FC | 46 | 2-1 → 2-2 | 0.27 | 0.39 | 0.74 | Mohamed Salah |
| 19/04/2022 | Home | Luis Díaz | Manchester United FC | 5 | 0-0 → 1-0 | 0.26 | 0.51 | 0.81 | Mohamed Salah |
| 19/04/2022 | Home | Mohamed Salah | Manchester United FC | 22 | 1-0 → 2-0 | 0.18 | 0.10 | 0.49 | Sadio Mané |
| 19/04/2022 | Home | Sadio Mané | Manchester United FC | 68 | 2-0 → 3-0 | 0.03 | 0.24 | 0.48 | Luis Díaz |
| 19/04/2022 | Home | Mohamed Salah | Manchester United FC | 85 | 3-0 → 4-0 | 0.00 | 0.20 | 0.03 | Diogo Jota |
| 24/04/2022 | Home | Andrew Robertson | Everton FC | 62 | 0-0 → 1-0 | 0.37 | 0.20 | 0.10 | Mohamed Salah |
| 24/04/2022 | Home | Divock Origi | Everton FC | 85 | 1-0 → 2-0 | 0.07 | 0.68 | 0.78 | Luis Díaz |
| 30/04/2022 | Away | Naby Keïta | Newcastle United FC | 19 | 0-0 → 0-1 | 0.25 | 0.74 | 0.64 | Diogo Jota |
| 07/05/2022 | Home | Luis Díaz | Tottenham Hotspur FC | 74 | 0-1 → 1-1 | 0.31 | 0.07 | 0.25 | Thiago Alcántara |
| 10/05/2022 | Away | Joël Matip | Aston Villa FC | 6 | 1-0 → 1-1 | 0.12 | 0.91 | 0.61 | - |
| 10/05/2022 | Away | Sadio Mané | Aston Villa FC | 65 | 1-1 → 1-2 | 0.41 | 0.22 | 0.32 | Luis Díaz |
| 17/05/2022 | Away | Takumi Minamino | Southampton FC | 27 | 1-0 → 1-1 | 0.25 | 0.05 | 0.35 | Diogo Jota |
| 17/05/2022 | Away | Joël Matip | Southampton FC | 67 | 1-1 → 1-2 | 0.40 | 0.02 | 0.49 | - |
| 22/05/2022 | Home | Sadio Mané | Wolverhampton Wanderers FC | 24 | 0-1 → 1-1 | 0.23 | 0.39 | 0.60 | Thiago Alcántara |
| 22/05/2022 | Home | Mohamed Salah | Wolverhampton Wanderers FC | 84 | 1-1 → 2-1 | 0.54 | 0.53 | 0.91 | Joël Matip |
| 22/05/2022 | Home | Andrew Robertson | Wolverhampton Wanderers FC | 89 | 2-1 → 3-1 | 0.04 | 0.13 | 0.92 | Roberto Firmino |