| 22/08/2009 | Away | Wayne Rooney | Wigan Athletic FC | 56 | 0-0 → 0-1 | 0.36 | - | - | Antonio Valencia |
| 22/08/2009 | Away | Dimitar Berbatov | Wigan Athletic FC | 58 | 0-1 → 0-2 | 0.16 | - | - | Paul Scholes |
| 22/08/2009 | Away | Wayne Rooney | Wigan Athletic FC | 65 | 0-2 → 0-3 | 0.03 | - | - | Dimitar Berbatov |
| 22/08/2009 | Away | Michael Owen | Wigan Athletic FC | 85 | 0-3 → 0-4 | 0.00 | - | - | Nani |
| 22/08/2009 | Away | Nani | Wigan Athletic FC | 90 | 0-4 → 0-5 | 0.00 | - | - | - |
| 29/08/2009 | Home | Wayne Rooney | Arsenal FC | 59 | 0-1 → 1-1 | 0.29 | - | - | - |
| 29/08/2009 | Home | Abou Diaby (OG) | Arsenal FC | 64 | 1-1 → 2-1 | 0.39 | - | - | - |
| 12/09/2009 | Away | Ryan Giggs | Tottenham Hotspur FC | 25 | 1-0 → 1-1 | 0.22 | - | - | - |
| 12/09/2009 | Away | Anderson | Tottenham Hotspur FC | 41 | 1-1 → 1-2 | 0.32 | - | - | - |
| 12/09/2009 | Away | Wayne Rooney | Tottenham Hotspur FC | 78 | 1-2 → 1-3 | 0.11 | - | - | Darren Fletcher |
| 20/09/2009 | Home | Wayne Rooney | Manchester City FC | 2 | 0-0 → 1-0 | 0.28 | - | - | Patrice Evra |
| 20/09/2009 | Home | Darren Fletcher | Manchester City FC | 49 | 1-1 → 2-1 | 0.34 | - | - | Ryan Giggs |
| 20/09/2009 | Home | Darren Fletcher | Manchester City FC | 81 | 2-2 → 3-2 | 0.50 | - | - | Ryan Giggs |
| 20/09/2009 | Home | Michael Owen | Manchester City FC | 96 | 3-2 → 4-2 | 0.01 | - | - | Ryan Giggs |
| 26/09/2009 | Away | Dimitar Berbatov | Stoke City FC | 62 | 0-0 → 0-1 | 0.37 | - | - | Ryan Giggs |
| 26/09/2009 | Away | John O'Shea | Stoke City FC | 77 | 0-1 → 0-2 | 0.11 | - | - | Ryan Giggs |
| 03/10/2009 | Home | Dimitar Berbatov | Sunderland AFC | 51 | 0-1 → 1-1 | 0.26 | - | - | John O'Shea |
| 03/10/2009 | Home | Anton Ferdinand (OG) | Sunderland AFC | 90 | 1-2 → 2-2 | 0.33 | - | - | - |
| 17/10/2009 | Home | Zat Knight (OG) | Bolton Wanderers FC | 5 | 0-0 → 1-0 | 0.26 | - | - | - |
| 17/10/2009 | Home | Antonio Valencia | Bolton Wanderers FC | 33 | 1-0 → 2-0 | 0.17 | - | - | Gary Neville |
| 31/10/2009 | Home | Dimitar Berbatov | Blackburn Rovers FC | 55 | 0-0 → 1-0 | 0.36 | - | - | Patrice Evra |
| 31/10/2009 | Home | Wayne Rooney | Blackburn Rovers FC | 87 | 1-0 → 2-0 | 0.05 | - | - | Anderson |
| 21/11/2009 | Home | Darren Fletcher | Everton FC | 35 | 0-0 → 1-0 | 0.30 | - | - | Antonio Valencia |
| 21/11/2009 | Home | Michael Carrick | Everton FC | 67 | 1-0 → 2-0 | 0.14 | - | - | Ryan Giggs |
| 21/11/2009 | Home | Antonio Valencia | Everton FC | 76 | 2-0 → 3-0 | 0.01 | - | - | Paul Scholes |
| 28/11/2009 | Away | Wayne Rooney | Portsmouth FC | 25 | 0-0 → 0-1 | 0.27 | - | - | - |
| 28/11/2009 | Away | Wayne Rooney | Portsmouth FC | 48 | 1-1 → 1-2 | 0.33 | - | - | Ryan Giggs |
| 28/11/2009 | Away | Wayne Rooney | Portsmouth FC | 54 | 1-2 → 1-3 | 0.15 | - | - | - |
| 28/11/2009 | Away | Ryan Giggs | Portsmouth FC | 87 | 1-3 → 1-4 | 0.00 | - | - | - |
| 05/12/2009 | Away | Paul Scholes | West Ham United FC | 45 | 0-0 → 0-1 | 0.31 | - | - | - |
| 05/12/2009 | Away | Darron Gibson | West Ham United FC | 61 | 0-1 → 0-2 | 0.16 | - | - | Ryan Giggs |
| 05/12/2009 | Away | Antonio Valencia | West Ham United FC | 70 | 0-2 → 0-3 | 0.03 | - | - | Anderson |
| 05/12/2009 | Away | Wayne Rooney | West Ham United FC | 72 | 0-3 → 0-4 | 0.00 | - | - | Antonio Valencia |
| 15/12/2009 | Home | Wayne Rooney | Wolverhampton Wanderers FC | 30 | 0-0 → 1-0 | 0.29 | - | - | - |
| 15/12/2009 | Home | Nemanja Vidić | Wolverhampton Wanderers FC | 43 | 1-0 → 2-0 | 0.16 | - | - | Darron Gibson |
| 15/12/2009 | Home | Antonio Valencia | Wolverhampton Wanderers FC | 66 | 2-0 → 3-0 | 0.03 | - | - | Dimitar Berbatov |
| 27/12/2009 | Away | Wayne Rooney | Hull City AFC | 47 | 0-0 → 0-1 | 0.32 | - | - | Darren Fletcher |
| 27/12/2009 | Away | Andy Dawson (OG) | Hull City AFC | 73 | 1-1 → 1-2 | 0.45 | - | - | - |
| 27/12/2009 | Away | Dimitar Berbatov | Hull City AFC | 82 | 1-2 → 1-3 | 0.09 | - | - | Wayne Rooney |
| 30/12/2009 | Home | Wayne Rooney | Wigan Athletic FC | 28 | 0-0 → 1-0 | 0.29 | - | - | Rafael |
| 30/12/2009 | Home | Michael Carrick | Wigan Athletic FC | 32 | 1-0 → 2-0 | 0.17 | - | - | Antonio Valencia |
| 30/12/2009 | Home | Rafael | Wigan Athletic FC | 45 | 2-0 → 3-0 | 0.06 | - | - | - |
| 30/12/2009 | Home | Dimitar Berbatov | Wigan Athletic FC | 50 | 3-0 → 4-0 | 0.01 | - | - | - |
| 30/12/2009 | Home | Antonio Valencia | Wigan Athletic FC | 75 | 4-0 → 5-0 | 0.00 | - | - | Wayne Rooney |
| 09/01/2010 | Away | Scott Dann (OG) | Birmingham City FC | 63 | 1-0 → 1-1 | 0.29 | - | - | - |
| 16/01/2010 | Home | Dimitar Berbatov | Burnley FC | 64 | 0-0 → 1-0 | 0.39 | - | - | Wayne Rooney |
| 16/01/2010 | Home | Wayne Rooney | Burnley FC | 69 | 1-0 → 2-0 | 0.13 | - | - | - |
| 16/01/2010 | Home | Mame Biram Diouf | Burnley FC | 91 | 2-0 → 3-0 | 0.00 | - | - | Antonio Valencia |
| 23/01/2010 | Home | Wayne Rooney | Hull City AFC | 8 | 0-0 → 1-0 | 0.26 | - | - | - |
| 23/01/2010 | Home | Wayne Rooney | Hull City AFC | 82 | 1-0 → 2-0 | 0.09 | - | - | Darron Gibson |
| 23/01/2010 | Home | Wayne Rooney | Hull City AFC | 86 | 2-0 → 3-0 | 0.00 | - | - | Nani |
| 23/01/2010 | Home | Wayne Rooney | Hull City AFC | 93 | 3-0 → 4-0 | 0.00 | - | - | Dimitar Berbatov |
| 31/01/2010 | Away | Nani | Arsenal FC | 33 | 0-0 → 0-1 | 0.30 | - | - | Michael Carrick |
| 31/01/2010 | Away | Wayne Rooney | Arsenal FC | 37 | 0-1 → 0-2 | 0.18 | - | - | Nani |
| 31/01/2010 | Away | Park Ji-sung | Arsenal FC | 52 | 0-2 → 0-3 | 0.05 | - | - | Michael Carrick |
| 06/02/2010 | Home | Wayne Rooney | Portsmouth FC | 40 | 0-0 → 1-0 | 0.31 | - | - | Darren Fletcher |
| 06/02/2010 | Home | Anthony Vanden Borre (OG) | Portsmouth FC | 45 | 1-0 → 2-0 | 0.16 | - | - | - |
| 06/02/2010 | Home | Richard Hughes (OG) | Portsmouth FC | 59 | 2-0 → 3-0 | 0.04 | - | - | - |
| 06/02/2010 | Home | Dimitar Berbatov | Portsmouth FC | 62 | 3-0 → 4-0 | 0.01 | - | - | - |
| 06/02/2010 | Home | Marc Wilson (OG) | Portsmouth FC | 69 | 4-0 → 5-0 | 0.00 | - | - | - |
| 10/02/2010 | Away | James Collins (OG) | Aston Villa FC | 23 | 1-0 → 1-1 | 0.23 | - | - | - |
| 20/02/2010 | Away | Dimitar Berbatov | Everton FC | 16 | 0-0 → 0-1 | 0.25 | - | - | - |
| 23/02/2010 | Home | Wayne Rooney | West Ham United FC | 38 | 0-0 → 1-0 | 0.29 | - | - | Antonio Valencia |
| 23/02/2010 | Home | Wayne Rooney | West Ham United FC | 55 | 1-0 → 2-0 | 0.15 | - | - | Antonio Valencia |
| 23/02/2010 | Home | Michael Owen | West Ham United FC | 80 | 2-0 → 3-0 | 0.01 | - | - | Paul Scholes |
| 06/03/2010 | Away | Paul Scholes | Wolverhampton Wanderers FC | 73 | 0-0 → 0-1 | 0.45 | - | - | - |
| 14/03/2010 | Home | Wayne Rooney | Fulham FC | 46 | 0-0 → 1-0 | 0.32 | - | - | Nani |
| 14/03/2010 | Home | Wayne Rooney | Fulham FC | 84 | 1-0 → 2-0 | 0.07 | - | - | Dimitar Berbatov |
| 14/03/2010 | Home | Dimitar Berbatov | Fulham FC | 89 | 2-0 → 3-0 | 0.00 | - | - | Park Ji-sung |
| 21/03/2010 | Home | Wayne Rooney | Liverpool FC | 12 | 0-1 → 1-1 | 0.21 | - | - | - |
| 21/03/2010 | Home | Park Ji-sung | Liverpool FC | 60 | 1-1 → 2-1 | 0.36 | - | - | Darren Fletcher |
| 27/03/2010 | Away | Jlloyd Samuel (OG) | Bolton Wanderers FC | 38 | 0-0 → 0-1 | 0.29 | - | - | - |
| 27/03/2010 | Away | Dimitar Berbatov | Bolton Wanderers FC | 69 | 0-1 → 0-2 | 0.13 | - | - | - |
| 27/03/2010 | Away | Dimitar Berbatov | Bolton Wanderers FC | 78 | 0-2 → 0-3 | 0.01 | - | - | Nani |
| 27/03/2010 | Away | Darron Gibson | Bolton Wanderers FC | 82 | 0-3 → 0-4 | 0.00 | - | - | Nani |
| 03/04/2010 | Home | Federico Macheda | Chelsea FC | 81 | 0-2 → 1-2 | 0.06 | - | - | - |
| 17/04/2010 | Away | Paul Scholes | Manchester City FC | 93 | 0-0 → 0-1 | 0.63 | - | - | Patrice Evra |
| 24/04/2010 | Home | Ryan Giggs | Tottenham Hotspur FC | 58 | 0-0 → 1-0 | 0.36 | - | - | - |
| 24/04/2010 | Home | Nani | Tottenham Hotspur FC | 81 | 1-1 → 2-1 | 0.50 | - | - | Federico Macheda |
| 24/04/2010 | Home | Ryan Giggs | Tottenham Hotspur FC | 86 | 2-1 → 3-1 | 0.06 | - | - | - |
| 02/05/2010 | Away | Nani | Sunderland AFC | 28 | 0-0 → 0-1 | 0.29 | - | - | Darren Fletcher |
| 09/05/2010 | Home | Darren Fletcher | Stoke City FC | 31 | 0-0 → 1-0 | 0.30 | - | - | - |
| 09/05/2010 | Home | Ryan Giggs | Stoke City FC | 38 | 1-0 → 2-0 | 0.18 | - | - | Dimitar Berbatov |
| 09/05/2010 | Home | Danny Higginbotham (OG) | Stoke City FC | 54 | 2-0 → 3-0 | 0.05 | - | - | - |
| 09/05/2010 | Home | Park Ji-sung | Stoke City FC | 84 | 3-0 → 4-0 | 0.00 | - | - | Ryan Giggs |