| 16/08/2010 | Home | Darren Fletcher | Newcastle United FC | 41 | 1-0 → 2-0 | 0.17 | - | - | Wayne Rooney |
| 16/08/2010 | Home | Ryan Giggs | Newcastle United FC | 85 | 2-0 → 3-0 | 0.00 | - | - | Paul Scholes |
| 22/08/2010 | Away | Paul Scholes | Fulham FC | 11 | 0-0 → 0-1 | 0.26 | - | - | Dimitar Berbatov |
| 22/08/2010 | Away | Brede Hangeland (OG) | Fulham FC | 84 | 1-1 → 1-2 | 0.54 | - | - | - |
| 28/08/2010 | Home | Wayne Rooney | West Ham United FC | 33 | 0-0 → 1-0 | 0.30 | - | - | - |
| 28/08/2010 | Home | Nani | West Ham United FC | 50 | 1-0 → 2-0 | 0.15 | - | - | Wayne Rooney |
| 28/08/2010 | Home | Dimitar Berbatov | West Ham United FC | 69 | 2-0 → 3-0 | 0.03 | - | - | Nani |
| 11/09/2010 | Away | Darren Fletcher | Everton FC | 43 | 1-0 → 1-1 | 0.26 | - | - | Nani |
| 11/09/2010 | Away | Nemanja Vidić | Everton FC | 47 | 1-1 → 1-2 | 0.32 | - | - | Nani |
| 11/09/2010 | Away | Dimitar Berbatov | Everton FC | 66 | 1-2 → 1-3 | 0.14 | - | - | Paul Scholes |
| 19/09/2010 | Home | Dimitar Berbatov | Liverpool FC | 42 | 0-0 → 1-0 | 0.31 | - | - | Ryan Giggs |
| 19/09/2010 | Home | Dimitar Berbatov | Liverpool FC | 59 | 1-0 → 2-0 | 0.16 | - | - | Nani |
| 19/09/2010 | Home | Dimitar Berbatov | Liverpool FC | 84 | 2-2 → 3-2 | 0.54 | - | - | John O'Shea |
| 26/09/2010 | Away | Nani | Bolton Wanderers FC | 23 | 1-0 → 1-1 | 0.23 | - | - | Wayne Rooney |
| 26/09/2010 | Away | Michael Owen | Bolton Wanderers FC | 74 | 2-1 → 2-2 | 0.31 | - | - | Nani |
| 16/10/2010 | Home | Javier Hernández | West Bromwich Albion FC | 5 | 0-0 → 1-0 | 0.26 | - | - | - |
| 16/10/2010 | Home | Nani | West Bromwich Albion FC | 25 | 1-0 → 2-0 | 0.18 | - | - | Dimitar Berbatov |
| 24/10/2010 | Away | Javier Hernández | Stoke City FC | 27 | 0-0 → 0-1 | 0.27 | - | - | Nemanja Vidić |
| 24/10/2010 | Away | Javier Hernández | Stoke City FC | 86 | 1-1 → 1-2 | 0.57 | - | - | - |
| 30/10/2010 | Home | Nemanja Vidić | Tottenham Hotspur FC | 31 | 0-0 → 1-0 | 0.30 | - | - | Nani |
| 30/10/2010 | Home | Nani | Tottenham Hotspur FC | 84 | 1-0 → 2-0 | 0.07 | - | - | - |
| 06/11/2010 | Home | Park Ji-sung | Wolverhampton Wanderers FC | 45 | 0-0 → 1-0 | 0.31 | - | - | Darren Fletcher |
| 06/11/2010 | Home | Park Ji-sung | Wolverhampton Wanderers FC | 93 | 1-1 → 2-1 | 0.63 | - | - | Darren Fletcher |
| 13/11/2010 | Away | Federico Macheda | Aston Villa FC | 81 | 2-0 → 2-1 | 0.06 | - | - | Darren Fletcher |
| 13/11/2010 | Away | Nemanja Vidić | Aston Villa FC | 85 | 2-1 → 2-2 | 0.32 | - | - | Nani |
| 20/11/2010 | Home | Patrice Evra | Wigan Athletic FC | 45 | 0-0 → 1-0 | 0.31 | - | - | Park Ji-sung |
| 20/11/2010 | Home | Javier Hernández | Wigan Athletic FC | 77 | 1-0 → 2-0 | 0.11 | - | - | Rafael |
| 27/11/2010 | Home | Dimitar Berbatov | Blackburn Rovers FC | 2 | 0-0 → 1-0 | 0.28 | - | - | Wayne Rooney |
| 27/11/2010 | Home | Park Ji-sung | Blackburn Rovers FC | 23 | 1-0 → 2-0 | 0.18 | - | - | Wayne Rooney |
| 27/11/2010 | Home | Dimitar Berbatov | Blackburn Rovers FC | 27 | 2-0 → 3-0 | 0.06 | - | - | - |
| 27/11/2010 | Home | Dimitar Berbatov | Blackburn Rovers FC | 47 | 3-0 → 4-0 | 0.01 | - | - | Nani |
| 27/11/2010 | Home | Nani | Blackburn Rovers FC | 48 | 4-0 → 5-0 | 0.00 | - | - | Anderson |
| 27/11/2010 | Home | Dimitar Berbatov | Blackburn Rovers FC | 62 | 5-0 → 6-0 | 0.00 | - | - | - |
| 27/11/2010 | Home | Dimitar Berbatov | Blackburn Rovers FC | 70 | 6-0 → 7-0 | 0.00 | - | - | - |
| 13/12/2010 | Home | Park Ji-sung | Arsenal FC | 41 | 0-0 → 1-0 | 0.32 | - | - | - |
| 26/12/2010 | Home | Dimitar Berbatov | Sunderland AFC | 5 | 0-0 → 1-0 | 0.26 | - | - | Wayne Rooney |
| 26/12/2010 | Home | Anton Ferdinand (OG) | Sunderland AFC | 57 | 1-0 → 2-0 | 0.16 | - | - | - |
| 28/12/2010 | Away | Dimitar Berbatov | Birmingham City FC | 58 | 0-0 → 0-1 | 0.36 | - | - | Darron Gibson |
| 01/01/2011 | Away | Wayne Rooney | West Bromwich Albion FC | 3 | 0-0 → 0-1 | 0.23 | - | - | Patrice Evra |
| 01/01/2011 | Away | Javier Hernández | West Bromwich Albion FC | 75 | 1-1 → 1-2 | 0.46 | - | - | Wayne Rooney |
| 04/01/2011 | Home | Javier Hernández | Stoke City FC | 27 | 0-0 → 1-0 | 0.27 | - | - | Nani |
| 04/01/2011 | Home | Nani | Stoke City FC | 62 | 1-1 → 2-1 | 0.37 | - | - | Javier Hernández |
| 22/01/2011 | Home | Dimitar Berbatov | Birmingham City FC | 2 | 0-0 → 1-0 | 0.28 | - | - | John O'Shea |
| 22/01/2011 | Home | Dimitar Berbatov | Birmingham City FC | 31 | 1-0 → 2-0 | 0.17 | - | - | Wayne Rooney |
| 22/01/2011 | Home | Ryan Giggs | Birmingham City FC | 47 | 2-0 → 3-0 | 0.06 | - | - | Wayne Rooney |
| 22/01/2011 | Home | Dimitar Berbatov | Birmingham City FC | 53 | 3-0 → 4-0 | 0.01 | - | - | Ryan Giggs |
| 22/01/2011 | Home | Nani | Birmingham City FC | 76 | 4-0 → 5-0 | 0.00 | - | - | John O'Shea |
| 25/01/2011 | Away | Dimitar Berbatov | Blackpool FC | 72 | 2-0 → 2-1 | 0.10 | - | - | Darren Fletcher |
| 25/01/2011 | Away | Javier Hernández | Blackpool FC | 74 | 2-1 → 2-2 | 0.31 | - | - | Ryan Giggs |
| 25/01/2011 | Away | Dimitar Berbatov | Blackpool FC | 88 | 2-2 → 2-3 | 0.60 | - | - | Paul Scholes |
| 01/02/2011 | Home | Wayne Rooney | Aston Villa FC | 1 | 0-0 → 1-0 | 0.28 | - | - | Edwin van der Sar |
| 01/02/2011 | Home | Wayne Rooney | Aston Villa FC | 46 | 1-0 → 2-0 | 0.16 | - | - | Nani |
| 01/02/2011 | Home | Nemanja Vidić | Aston Villa FC | 63 | 2-1 → 3-1 | 0.15 | - | - | Wayne Rooney |
| 05/02/2011 | Away | Nani | Wolverhampton Wanderers FC | 3 | 0-0 → 0-1 | 0.23 | - | - | Darren Fletcher |
| 12/02/2011 | Home | Nani | Manchester City FC | 41 | 0-0 → 1-0 | 0.32 | - | - | Ryan Giggs |
| 12/02/2011 | Home | Wayne Rooney | Manchester City FC | 78 | 1-1 → 2-1 | 0.46 | - | - | Nani |
| 26/02/2011 | Away | Javier Hernández | Wigan Athletic FC | 17 | 0-0 → 0-1 | 0.25 | - | - | Nani |
| 26/02/2011 | Away | Javier Hernández | Wigan Athletic FC | 74 | 0-1 → 0-2 | 0.12 | - | - | Wayne Rooney |
| 26/02/2011 | Away | Wayne Rooney | Wigan Athletic FC | 84 | 0-2 → 0-3 | 0.00 | - | - | Dimitar Berbatov |
| 26/02/2011 | Away | Fábio | Wigan Athletic FC | 87 | 0-3 → 0-4 | 0.00 | - | - | Darren Fletcher |
| 01/03/2011 | Away | Wayne Rooney | Chelsea FC | 29 | 0-0 → 0-1 | 0.30 | - | - | Nani |
| 06/03/2011 | Away | Javier Hernández | Liverpool FC | 92 | 3-0 → 3-1 | 0.00 | - | - | Ryan Giggs |
| 19/03/2011 | Home | Dimitar Berbatov | Bolton Wanderers FC | 88 | 0-0 → 1-0 | 0.60 | - | - | - |
| 02/04/2011 | Away | Wayne Rooney | West Ham United FC | 65 | 2-0 → 2-1 | 0.11 | - | - | - |
| 02/04/2011 | Away | Wayne Rooney | West Ham United FC | 73 | 2-1 → 2-2 | 0.31 | - | - | Antonio Valencia |
| 02/04/2011 | Away | Wayne Rooney | West Ham United FC | 79 | 2-2 → 2-3 | 0.47 | - | - | - |
| 02/04/2011 | Away | Javier Hernández | West Ham United FC | 84 | 2-3 → 2-4 | 0.07 | - | - | - |
| 09/04/2011 | Home | Dimitar Berbatov | Fulham FC | 12 | 0-0 → 1-0 | 0.26 | - | - | Nani |
| 09/04/2011 | Home | Antonio Valencia | Fulham FC | 32 | 1-0 → 2-0 | 0.17 | - | - | - |
| 23/04/2011 | Home | Javier Hernández | Everton FC | 83 | 0-0 → 1-0 | 0.53 | - | - | Antonio Valencia |
| 08/05/2011 | Home | Javier Hernández | Chelsea FC | 1 | 0-0 → 1-0 | 0.28 | - | - | Park Ji-sung |
| 08/05/2011 | Home | Nemanja Vidić | Chelsea FC | 23 | 1-0 → 2-0 | 0.18 | - | - | Ryan Giggs |
| 14/05/2011 | Away | Wayne Rooney | Blackburn Rovers FC | 73 | 1-0 → 1-1 | 0.31 | - | - | - |
| 22/05/2011 | Home | Park Ji-sung | Blackpool FC | 21 | 0-0 → 1-0 | 0.28 | - | - | Dimitar Berbatov |
| 22/05/2011 | Home | Anderson | Blackpool FC | 63 | 1-2 → 2-2 | 0.29 | - | - | Park Ji-sung |
| 22/05/2011 | Home | Ian Evatt (OG) | Blackpool FC | 74 | 2-2 → 3-2 | 0.45 | - | - | - |
| 22/05/2011 | Home | Michael Owen | Blackpool FC | 81 | 3-2 → 4-2 | 0.09 | - | - | Anderson |