| 26/09/2020 | Away | Lewis Dunk (OG) | Brighton & Hove Albion FC | 43 | 1-0 → 1-1 | 0.26 | - | - | - |
| 26/09/2020 | Away | Marcus Rashford | Brighton & Hove Albion FC | 55 | 1-1 → 1-2 | 0.36 | 0.51 | 0.97 | Bruno Fernandes |
| 26/09/2020 | Away | Bruno Fernandes | Brighton & Hove Albion FC | 100 | 2-2 → 2-3 | 0.65 | 0.79 | 0.98 | - |
| 04/10/2020 | Home | Bruno Fernandes | Tottenham Hotspur FC | 2 | 0-0 → 1-0 | 0.28 | 0.79 | 0.97 | - |
| 17/10/2020 | Away | Harry Maguire | Newcastle United FC | 23 | 1-0 → 1-1 | 0.23 | 0.07 | 0.19 | Juan Mata |
| 17/10/2020 | Away | Bruno Fernandes | Newcastle United FC | 86 | 1-1 → 1-2 | 0.57 | 0.10 | 0.92 | Marcus Rashford |
| 17/10/2020 | Away | Aaron Wan-Bissaka | Newcastle United FC | 90 | 1-2 → 1-3 | 0.03 | 0.06 | 0.38 | Marcus Rashford |
| 17/10/2020 | Away | Marcus Rashford | Newcastle United FC | 96 | 1-3 → 1-4 | 0.00 | 0.29 | 0.30 | Bruno Fernandes |
| 07/11/2020 | Away | Bruno Fernandes | Everton FC | 25 | 1-0 → 1-1 | 0.22 | 0.20 | 0.66 | Luke Shaw |
| 07/11/2020 | Away | Bruno Fernandes | Everton FC | 32 | 1-1 → 1-2 | 0.30 | 0.03 | 0.49 | Marcus Rashford |
| 07/11/2020 | Away | Edinson Cavani | Everton FC | 95 | 1-2 → 1-3 | 0.01 | 0.36 | 0.67 | Bruno Fernandes |
| 21/11/2020 | Home | Bruno Fernandes | West Bromwich Albion FC | 56 | 0-0 → 1-0 | 0.36 | 0.79 | 0.98 | - |
| 29/11/2020 | Away | Bruno Fernandes | Southampton FC | 59 | 2-0 → 2-1 | 0.12 | 0.32 | 0.57 | Edinson Cavani |
| 29/11/2020 | Away | Edinson Cavani | Southampton FC | 74 | 2-1 → 2-2 | 0.31 | 0.10 | 0.20 | - |
| 29/11/2020 | Away | Edinson Cavani | Southampton FC | 92 | 2-2 → 2-3 | 0.63 | 0.10 | 0.16 | Marcus Rashford |
| 05/12/2020 | Away | Paul Pogba | West Ham United FC | 65 | 1-0 → 1-1 | 0.28 | 0.03 | 0.43 | Bruno Fernandes |
| 05/12/2020 | Away | Mason Greenwood | West Ham United FC | 68 | 1-1 → 1-2 | 0.41 | 0.06 | 0.09 | Alex Telles |
| 05/12/2020 | Away | Marcus Rashford | West Ham United FC | 78 | 1-2 → 1-3 | 0.11 | 0.48 | 0.49 | Juan Mata |
| 17/12/2020 | Away | Marcus Rashford | Sheffield United FC | 26 | 1-0 → 1-1 | 0.23 | 0.05 | 0.06 | Victor Lindelöf |
| 17/12/2020 | Away | Anthony Martial | Sheffield United FC | 33 | 1-1 → 1-2 | 0.30 | 0.37 | 0.31 | - |
| 17/12/2020 | Away | Marcus Rashford | Sheffield United FC | 51 | 1-2 → 1-3 | 0.15 | 0.06 | 0.04 | Anthony Martial |
| 20/12/2020 | Home | Scott McTominay | Leeds United FC | 2 | 0-0 → 1-0 | 0.28 | 0.05 | 0.33 | Bruno Fernandes |
| 20/12/2020 | Home | Scott McTominay | Leeds United FC | 3 | 1-0 → 2-0 | 0.18 | 0.39 | 0.88 | Anthony Martial |
| 20/12/2020 | Home | Bruno Fernandes | Leeds United FC | 20 | 2-0 → 3-0 | 0.07 | 0.11 | 0.10 | - |
| 20/12/2020 | Home | Victor Lindelöf | Leeds United FC | 37 | 3-0 → 4-0 | 0.01 | 0.26 | 0.17 | Anthony Martial |
| 20/12/2020 | Home | Daniel James | Leeds United FC | 66 | 4-1 → 5-1 | 0.00 | 0.27 | 0.14 | Scott McTominay |
| 20/12/2020 | Home | Bruno Fernandes | Leeds United FC | 70 | 5-1 → 6-1 | 0.00 | 0.79 | 0.99 | - |
| 26/12/2020 | Away | Marcus Rashford | Leicester City FC | 23 | 0-0 → 0-1 | 0.27 | 0.34 | 0.86 | Bruno Fernandes |
| 26/12/2020 | Away | Bruno Fernandes | Leicester City FC | 79 | 1-1 → 1-2 | 0.47 | 0.41 | 0.88 | Edinson Cavani |
| 29/12/2020 | Home | Marcus Rashford | Wolverhampton Wanderers FC | 93 | 0-0 → 1-0 | 0.63 | 0.05 | 0.35 | Bruno Fernandes |
| 01/01/2021 | Home | Anthony Martial | Aston Villa FC | 40 | 0-0 → 1-0 | 0.31 | 0.28 | 0.07 | Aaron Wan-Bissaka |
| 01/01/2021 | Home | Bruno Fernandes | Aston Villa FC | 61 | 1-1 → 2-1 | 0.37 | 0.79 | 0.99 | - |
| 12/01/2021 | Away | Paul Pogba | Burnley FC | 71 | 0-0 → 0-1 | 0.42 | 0.06 | 0.02 | Marcus Rashford |
| 20/01/2021 | Away | Edinson Cavani | Fulham FC | 21 | 1-0 → 1-1 | 0.26 | 0.55 | 0.88 | - |
| 20/01/2021 | Away | Paul Pogba | Fulham FC | 65 | 1-1 → 1-2 | 0.41 | 0.04 | 0.43 | - |
| 27/01/2021 | Home | Harry Maguire | Sheffield United FC | 64 | 0-1 → 1-1 | 0.29 | 0.07 | 0.17 | Alex Telles |
| 02/02/2021 | Home | Aaron Wan-Bissaka | Southampton FC | 18 | 0-0 → 1-0 | 0.26 | 0.68 | 0.99 | Luke Shaw |
| 02/02/2021 | Home | Marcus Rashford | Southampton FC | 25 | 1-0 → 2-0 | 0.18 | 0.34 | 0.21 | Mason Greenwood |
| 02/02/2021 | Home | Jan Bednarek (OG) | Southampton FC | 34 | 2-0 → 3-0 | 0.06 | - | - | - |
| 02/02/2021 | Home | Edinson Cavani | Southampton FC | 39 | 3-0 → 4-0 | 0.02 | 0.28 | 0.49 | Luke Shaw |
| 02/02/2021 | Home | Anthony Martial | Southampton FC | 69 | 4-0 → 5-0 | 0.00 | 0.29 | 0.70 | Bruno Fernandes |
| 02/02/2021 | Home | Scott McTominay | Southampton FC | 71 | 5-0 → 6-0 | 0.00 | 0.03 | 0.10 | - |
| 02/02/2021 | Home | Bruno Fernandes | Southampton FC | 87 | 6-0 → 7-0 | 0.00 | 0.79 | 0.96 | - |
| 02/02/2021 | Home | Anthony Martial | Southampton FC | 90 | 7-0 → 8-0 | 0.00 | 0.60 | 0.92 | - |
| 02/02/2021 | Home | Daniel James | Southampton FC | 93 | 8-0 → 9-0 | 0.00 | 0.65 | 0.88 | Bruno Fernandes |
| 06/02/2021 | Home | Edinson Cavani | Everton FC | 24 | 0-0 → 1-0 | 0.27 | 0.53 | 0.66 | Marcus Rashford |
| 06/02/2021 | Home | Bruno Fernandes | Everton FC | 45 | 1-0 → 2-0 | 0.16 | 0.03 | 0.20 | Aaron Wan-Bissaka |
| 06/02/2021 | Home | Scott McTominay | Everton FC | 70 | 2-2 → 3-2 | 0.42 | 0.08 | 0.24 | Luke Shaw |
| 14/02/2021 | Away | Bruno Fernandes | West Bromwich Albion FC | 44 | 1-0 → 1-1 | 0.26 | 0.09 | 0.42 | Luke Shaw |
| 21/02/2021 | Home | Marcus Rashford | Newcastle United FC | 30 | 0-0 → 1-0 | 0.29 | 0.05 | 0.15 | Harry Maguire |
| 21/02/2021 | Home | Daniel James | Newcastle United FC | 57 | 1-1 → 2-1 | 0.36 | 0.29 | 0.47 | Bruno Fernandes |
| 21/02/2021 | Home | Bruno Fernandes | Newcastle United FC | 75 | 2-1 → 3-1 | 0.11 | 0.79 | 0.99 | - |
| 07/03/2021 | Away | Bruno Fernandes | Manchester City FC | 2 | 0-0 → 0-1 | 0.28 | 0.79 | 0.99 | - |
| 07/03/2021 | Away | Luke Shaw | Manchester City FC | 50 | 0-1 → 0-2 | 0.15 | 0.06 | 0.46 | Marcus Rashford |
| 14/03/2021 | Home | Craig Dawson (OG) | West Ham United FC | 53 | 0-0 → 1-0 | 0.35 | - | - | - |
| 04/04/2021 | Home | Marcus Rashford | Brighton & Hove Albion FC | 62 | 0-1 → 1-1 | 0.29 | 0.25 | 0.69 | Bruno Fernandes |
| 04/04/2021 | Home | Mason Greenwood | Brighton & Hove Albion FC | 83 | 1-1 → 2-1 | 0.53 | 0.42 | 0.29 | Paul Pogba |
| 11/04/2021 | Away | Fred | Tottenham Hotspur FC | 57 | 1-0 → 1-1 | 0.29 | 0.72 | 0.96 | - |
| 11/04/2021 | Away | Edinson Cavani | Tottenham Hotspur FC | 79 | 1-1 → 1-2 | 0.47 | 0.25 | 0.56 | Mason Greenwood |
| 11/04/2021 | Away | Mason Greenwood | Tottenham Hotspur FC | 96 | 1-2 → 1-3 | 0.01 | 0.06 | 0.11 | Paul Pogba |
| 18/04/2021 | Home | Mason Greenwood | Burnley FC | 48 | 0-0 → 1-0 | 0.33 | 0.31 | 0.24 | Marcus Rashford |
| 18/04/2021 | Home | Mason Greenwood | Burnley FC | 84 | 1-1 → 2-1 | 0.54 | 0.02 | 0.05 | Paul Pogba |
| 18/04/2021 | Home | Edinson Cavani | Burnley FC | 93 | 2-1 → 3-1 | 0.02 | 0.84 | 0.92 | Donny van de Beek |
| 09/05/2021 | Away | Bruno Fernandes | Aston Villa FC | 52 | 1-0 → 1-1 | 0.27 | 0.79 | 0.99 | - |
| 09/05/2021 | Away | Mason Greenwood | Aston Villa FC | 56 | 1-1 → 1-2 | 0.36 | 0.04 | 0.20 | Aaron Wan-Bissaka |
| 09/05/2021 | Away | Edinson Cavani | Aston Villa FC | 87 | 1-2 → 1-3 | 0.05 | 0.29 | 0.70 | Marcus Rashford |
| 11/05/2021 | Home | Mason Greenwood | Leicester City FC | 15 | 0-1 → 1-1 | 0.21 | 0.05 | 0.56 | Amad Diallo |
| 13/05/2021 | Home | Bruno Fernandes | Liverpool FC | 10 | 0-0 → 1-0 | 0.26 | 0.06 | 0.03 | Aaron Wan-Bissaka |
| 13/05/2021 | Home | Marcus Rashford | Liverpool FC | 68 | 1-3 → 2-3 | 0.09 | 0.09 | 0.62 | Edinson Cavani |
| 18/05/2021 | Home | Edinson Cavani | Fulham FC | 15 | 0-0 → 1-0 | 0.24 | 0.04 | 0.09 | Bruno Fernandes |
| 23/05/2021 | Away | Anthony Elanga | Wolverhampton Wanderers FC | 13 | 0-0 → 0-1 | 0.26 | 0.31 | 0.60 | Daniel James |
| 23/05/2021 | Away | Juan Mata | Wolverhampton Wanderers FC | 49 | 1-1 → 1-2 | 0.34 | 0.79 | 0.99 | - |