| 14/08/2021 | Home | Mason Greenwood | Leeds United FC | 52 | 1-1 → 2-1 | 0.35 | 0.08 | 0.60 | Paul Pogba |
| 14/08/2021 | Home | Bruno Fernandes | Leeds United FC | 54 | 2-1 → 3-1 | 0.15 | 0.14 | 0.08 | Paul Pogba |
| 14/08/2021 | Home | Bruno Fernandes | Leeds United FC | 60 | 3-1 → 4-1 | 0.03 | 0.23 | 0.27 | Victor Lindelöf |
| 14/08/2021 | Home | Fred | Leeds United FC | 68 | 4-1 → 5-1 | 0.00 | 0.18 | 0.07 | Paul Pogba |
| 22/08/2021 | Away | Mason Greenwood | Southampton FC | 55 | 1-0 → 1-1 | 0.26 | 0.14 | 0.06 | Paul Pogba |
| 29/08/2021 | Away | Mason Greenwood | Wolverhampton Wanderers FC | 80 | 0-0 → 0-1 | 0.48 | 0.02 | 0.24 | Raphaël Varane |
| 11/09/2021 | Home | Cristiano Ronaldo | Newcastle United FC | 47 | 0-0 → 1-0 | 0.32 | 0.93 | 0.97 | - |
| 11/09/2021 | Home | Cristiano Ronaldo | Newcastle United FC | 62 | 1-1 → 2-1 | 0.37 | 0.17 | 0.11 | Luke Shaw |
| 11/09/2021 | Home | Bruno Fernandes | Newcastle United FC | 80 | 2-1 → 3-1 | 0.10 | 0.04 | 0.23 | Paul Pogba |
| 11/09/2021 | Home | Jesse Lingard | Newcastle United FC | 92 | 3-1 → 4-1 | 0.00 | 0.33 | 0.74 | Paul Pogba |
| 19/09/2021 | Away | Cristiano Ronaldo | West Ham United FC | 35 | 1-0 → 1-1 | 0.27 | 0.92 | 1.00 | - |
| 19/09/2021 | Away | Jesse Lingard | West Ham United FC | 89 | 1-1 → 1-2 | 0.61 | 0.05 | 0.59 | Nemanja Matić |
| 02/10/2021 | Home | Anthony Martial | Everton FC | 43 | 0-0 → 1-0 | 0.31 | 0.06 | 0.06 | Bruno Fernandes |
| 16/10/2021 | Away | Mason Greenwood | Leicester City FC | 19 | 0-0 → 0-1 | 0.25 | 0.02 | 0.61 | Bruno Fernandes |
| 16/10/2021 | Away | Marcus Rashford | Leicester City FC | 82 | 2-1 → 2-2 | 0.32 | 0.32 | 0.16 | Victor Lindelöf |
| 30/10/2021 | Away | Cristiano Ronaldo | Tottenham Hotspur FC | 39 | 0-0 → 0-1 | 0.31 | 0.04 | 0.54 | Bruno Fernandes |
| 30/10/2021 | Away | Edinson Cavani | Tottenham Hotspur FC | 64 | 0-1 → 0-2 | 0.15 | 0.55 | 0.82 | Cristiano Ronaldo |
| 30/10/2021 | Away | Marcus Rashford | Tottenham Hotspur FC | 86 | 0-2 → 0-3 | 0.00 | 0.45 | 0.64 | Nemanja Matić |
| 20/11/2021 | Away | Donny van de Beek | Watford FC | 50 | 2-0 → 2-1 | 0.11 | 0.33 | 0.63 | Cristiano Ronaldo |
| 28/11/2021 | Away | Jadon Sancho | Chelsea FC | 50 | 0-0 → 0-1 | 0.35 | 0.81 | 0.96 | - |
| 02/12/2021 | Home | Bruno Fernandes | Arsenal FC | 44 | 0-1 → 1-1 | 0.26 | 0.16 | 0.11 | Fred |
| 02/12/2021 | Home | Cristiano Ronaldo | Arsenal FC | 52 | 1-1 → 2-1 | 0.35 | 0.53 | 0.91 | Marcus Rashford |
| 02/12/2021 | Home | Cristiano Ronaldo | Arsenal FC | 70 | 2-2 → 3-2 | 0.42 | 0.79 | 0.93 | - |
| 05/12/2021 | Home | Fred | Crystal Palace FC | 77 | 0-0 → 1-0 | 0.46 | 0.04 | 0.58 | Mason Greenwood |
| 11/12/2021 | Away | Cristiano Ronaldo | Norwich City FC | 75 | 0-0 → 0-1 | 0.46 | 0.79 | 0.98 | - |
| 27/12/2021 | Away | Edinson Cavani | Newcastle United FC | 71 | 1-0 → 1-1 | 0.32 | 0.41 | 0.58 | - |
| 30/12/2021 | Home | Scott McTominay | Burnley FC | 8 | 0-0 → 1-0 | 0.26 | 0.04 | 0.26 | Cristiano Ronaldo |
| 30/12/2021 | Home | Ben Mee (OG) | Burnley FC | 27 | 1-0 → 2-0 | 0.18 | - | - | - |
| 30/12/2021 | Home | Cristiano Ronaldo | Burnley FC | 35 | 2-0 → 3-0 | 0.06 | 0.92 | 0.41 | - |
| 15/01/2022 | Away | Bruno Fernandes | Aston Villa FC | 6 | 0-0 → 0-1 | 0.25 | 0.02 | 0.10 | Alex Telles |
| 15/01/2022 | Away | Bruno Fernandes | Aston Villa FC | 67 | 0-1 → 0-2 | 0.14 | 0.19 | 0.68 | Fred |
| 19/01/2022 | Away | Anthony Elanga | Brentford FC | 55 | 0-0 → 0-1 | 0.36 | 0.47 | 0.97 | Fred |
| 19/01/2022 | Away | Mason Greenwood | Brentford FC | 62 | 0-1 → 0-2 | 0.16 | 0.93 | 0.81 | Bruno Fernandes |
| 19/01/2022 | Away | Marcus Rashford | Brentford FC | 77 | 0-2 → 0-3 | 0.01 | 0.11 | 0.63 | Bruno Fernandes |
| 22/01/2022 | Home | Marcus Rashford | West Ham United FC | 93 | 0-0 → 1-0 | 0.63 | 0.89 | 0.98 | Edinson Cavani |
| 08/02/2022 | Away | Paul Pogba | Burnley FC | 18 | 0-0 → 0-1 | 0.26 | 0.28 | 0.43 | Luke Shaw |
| 12/02/2022 | Home | Jadon Sancho | Southampton FC | 21 | 0-0 → 1-0 | 0.28 | 0.40 | 0.98 | Marcus Rashford |
| 15/02/2022 | Home | Cristiano Ronaldo | Brighton & Hove Albion FC | 51 | 0-0 → 1-0 | 0.35 | 0.05 | 0.45 | Scott McTominay |
| 15/02/2022 | Home | Bruno Fernandes | Brighton & Hove Albion FC | 97 | 1-0 → 2-0 | 0.01 | 0.09 | 0.13 | Paul Pogba |
| 20/02/2022 | Away | Harry Maguire | Leeds United FC | 34 | 0-0 → 0-1 | 0.29 | 0.11 | 0.08 | Luke Shaw |
| 20/02/2022 | Away | Bruno Fernandes | Leeds United FC | 50 | 0-1 → 0-2 | 0.15 | 0.37 | 0.20 | Jadon Sancho |
| 20/02/2022 | Away | Fred | Leeds United FC | 70 | 2-2 → 2-3 | 0.42 | 0.07 | 0.15 | Jadon Sancho |
| 20/02/2022 | Away | Anthony Elanga | Leeds United FC | 88 | 2-3 → 2-4 | 0.04 | 0.31 | 0.19 | Bruno Fernandes |
| 06/03/2022 | Away | Jadon Sancho | Manchester City FC | 22 | 1-0 → 1-1 | 0.24 | 0.07 | 0.57 | Paul Pogba |
| 12/03/2022 | Home | Cristiano Ronaldo | Tottenham Hotspur FC | 12 | 0-0 → 1-0 | 0.26 | 0.03 | 0.24 | Fred |
| 12/03/2022 | Home | Cristiano Ronaldo | Tottenham Hotspur FC | 38 | 1-1 → 2-1 | 0.29 | 0.50 | 0.57 | Jadon Sancho |
| 12/03/2022 | Home | Cristiano Ronaldo | Tottenham Hotspur FC | 81 | 2-2 → 3-2 | 0.50 | 0.04 | 0.30 | Alex Telles |
| 02/04/2022 | Home | Fred | Leicester City FC | 66 | 0-1 → 1-1 | 0.28 | 0.31 | 0.49 | - |
| 16/04/2022 | Home | Cristiano Ronaldo | Norwich City FC | 7 | 0-0 → 1-0 | 0.25 | 0.76 | 0.25 | Anthony Elanga |
| 16/04/2022 | Home | Cristiano Ronaldo | Norwich City FC | 32 | 1-0 → 2-0 | 0.17 | 0.09 | 0.11 | Alex Telles |
| 16/04/2022 | Home | Cristiano Ronaldo | Norwich City FC | 76 | 2-2 → 3-2 | 0.46 | 0.03 | 0.47 | - |
| 23/04/2022 | Away | Cristiano Ronaldo | Arsenal FC | 34 | 2-0 → 2-1 | 0.14 | 0.45 | 0.74 | Nemanja Matić |
| 28/04/2022 | Home | Cristiano Ronaldo | Chelsea FC | 62 | 0-1 → 1-1 | 0.29 | 0.29 | 0.32 | Nemanja Matić |
| 02/05/2022 | Home | Bruno Fernandes | Brentford FC | 9 | 0-0 → 1-0 | 0.27 | 0.60 | 0.54 | Anthony Elanga |
| 02/05/2022 | Home | Cristiano Ronaldo | Brentford FC | 61 | 1-0 → 2-0 | 0.16 | 0.79 | 0.98 | - |
| 02/05/2022 | Home | Raphaël Varane | Brentford FC | 72 | 2-0 → 3-0 | 0.02 | 0.11 | 0.08 | Alex Telles |