| 15/08/2021 | Home | Jacob Murphy | West Ham United FC | 40 | 1-1 → 2-1 | 0.31 | 0.12 | 0.47 | Matt Ritchie |
| 28/08/2021 | Home | Callum Wilson | Southampton FC | 55 | 0-0 → 1-0 | 0.36 | 0.18 | 0.27 | Jacob Murphy |
| 28/08/2021 | Home | Allan Saint-Maximin | Southampton FC | 90 | 1-1 → 2-1 | 0.61 | 0.39 | 0.39 | - |
| 11/09/2021 | Away | Javier Manquillo | Manchester United FC | 56 | 1-0 → 1-1 | 0.28 | 0.17 | 0.56 | Allan Saint-Maximin |
| 17/09/2021 | Home | Allan Saint-Maximin | Leeds United FC | 44 | 0-1 → 1-1 | 0.26 | 0.13 | 0.21 | Joelinton |
| 25/09/2021 | Away | Sean Longstaff | Watford FC | 23 | 0-0 → 0-1 | 0.27 | 0.03 | 0.58 | Allan Saint-Maximin |
| 02/10/2021 | Away | Jeff Hendrick | Wolverhampton Wanderers FC | 41 | 1-0 → 1-1 | 0.25 | 0.09 | 0.40 | Javier Manquillo |
| 17/10/2021 | Home | Callum Wilson | Tottenham Hotspur FC | 2 | 0-0 → 1-0 | 0.28 | 0.20 | 0.15 | Javier Manquillo |
| 17/10/2021 | Home | Eric Dier (OG) | Tottenham Hotspur FC | 89 | 1-3 → 2-3 | 0.03 | - | - | - |
| 23/10/2021 | Away | Callum Wilson | Crystal Palace FC | 65 | 1-0 → 1-1 | 0.28 | 0.05 | 0.47 | Emil Krafth |
| 06/11/2021 | Away | Isaac Hayden | Brighton & Hove Albion FC | 66 | 1-0 → 1-1 | 0.28 | 0.17 | 0.18 | Ciaran Clark |
| 20/11/2021 | Home | Jamaal Lascelles | Brentford FC | 10 | 0-0 → 1-0 | 0.26 | 0.09 | 0.45 | Matt Ritchie |
| 20/11/2021 | Home | Joelinton | Brentford FC | 39 | 1-2 → 2-2 | 0.26 | 0.10 | 0.42 | - |
| 20/11/2021 | Home | Allan Saint-Maximin | Brentford FC | 75 | 2-3 → 3-3 | 0.32 | 0.20 | 0.42 | Ryan Fraser |
| 30/11/2021 | Home | Callum Wilson | Norwich City FC | 61 | 0-0 → 1-0 | 0.37 | 0.79 | 0.97 | - |
| 04/12/2021 | Home | Callum Wilson | Burnley FC | 40 | 0-0 → 1-0 | 0.31 | 0.10 | 0.09 | Fabian Schär |
| 16/12/2021 | Away | Jonjo Shelvey | Liverpool FC | 7 | 0-0 → 0-1 | 0.25 | 0.04 | 0.36 | - |
| 27/12/2021 | Home | Allan Saint-Maximin | Manchester United FC | 7 | 0-0 → 1-0 | 0.25 | 0.08 | 0.41 | Sean Longstaff |
| 15/01/2022 | Home | Allan Saint-Maximin | Watford FC | 49 | 0-0 → 1-0 | 0.34 | 0.06 | 0.15 | - |
| 22/01/2022 | Away | Jonjo Shelvey | Leeds United FC | 75 | 0-0 → 0-1 | 0.46 | 0.05 | 0.41 | - |
| 08/02/2022 | Home | Mason Holgate (OG) | Everton FC | 37 | 0-1 → 1-1 | 0.25 | - | - | - |
| 08/02/2022 | Home | Ryan Fraser | Everton FC | 56 | 1-1 → 2-1 | 0.36 | 0.32 | 0.72 | - |
| 08/02/2022 | Home | Kieran Trippier | Everton FC | 80 | 2-1 → 3-1 | 0.10 | 0.07 | 0.36 | - |
| 13/02/2022 | Home | Kieran Trippier | Aston Villa FC | 35 | 0-0 → 1-0 | 0.30 | 0.16 | 0.10 | - |
| 19/02/2022 | Away | Joe Willock | West Ham United FC | 46 | 1-0 → 1-1 | 0.27 | 0.10 | 0.04 | - |
| 26/02/2022 | Away | Joelinton | Brentford FC | 33 | 0-0 → 0-1 | 0.30 | 0.13 | 0.16 | Ryan Fraser |
| 26/02/2022 | Away | Joe Willock | Brentford FC | 44 | 0-1 → 0-2 | 0.16 | 0.57 | 0.80 | Fabian Schär |
| 05/03/2022 | Home | Ryan Fraser | Brighton & Hove Albion FC | 12 | 0-0 → 1-0 | 0.26 | 0.80 | 0.99 | - |
| 05/03/2022 | Home | Fabian Schär | Brighton & Hove Albion FC | 14 | 1-0 → 2-0 | 0.18 | 0.08 | 0.35 | Ryan Fraser |
| 10/03/2022 | Away | Chris Wood | Southampton FC | 32 | 1-0 → 1-1 | 0.27 | 0.17 | 0.32 | Jonjo Shelvey |
| 10/03/2022 | Away | Bruno Guimarães | Southampton FC | 52 | 1-1 → 1-2 | 0.35 | 0.18 | 0.28 | Dan Burn |
| 03/04/2022 | Away | Fabian Schär | Tottenham Hotspur FC | 39 | 0-0 → 0-1 | 0.31 | 0.08 | 0.58 | - |
| 08/04/2022 | Home | Chris Wood | Wolverhampton Wanderers FC | 72 | 0-0 → 1-0 | 0.44 | 0.79 | 0.97 | - |
| 17/04/2022 | Home | Bruno Guimarães | Leicester City FC | 30 | 0-1 → 1-1 | 0.26 | 0.52 | 0.66 | - |
| 17/04/2022 | Home | Bruno Guimarães | Leicester City FC | 95 | 1-1 → 2-1 | 0.65 | 0.41 | 0.97 | - |
| 20/04/2022 | Home | Miguel Almirón | Crystal Palace FC | 32 | 0-0 → 1-0 | 0.30 | 0.10 | 0.68 | Bruno Guimarães |
| 23/04/2022 | Away | Joelinton | Norwich City FC | 35 | 0-0 → 0-1 | 0.30 | 0.05 | 0.17 | Allan Saint-Maximin |
| 23/04/2022 | Away | Joelinton | Norwich City FC | 41 | 0-1 → 0-2 | 0.17 | 0.57 | 0.79 | Jacob Murphy |
| 23/04/2022 | Away | Bruno Guimarães | Norwich City FC | 49 | 0-2 → 0-3 | 0.05 | 0.49 | 0.26 | - |
| 16/05/2022 | Home | Ben White (OG) | Arsenal FC | 55 | 0-0 → 1-0 | 0.36 | - | - | - |
| 16/05/2022 | Home | Bruno Guimarães | Arsenal FC | 85 | 1-0 → 2-0 | 0.07 | 0.24 | 0.81 | - |
| 22/05/2022 | Away | Callum Wilson | Burnley FC | 20 | 0-0 → 0-1 | 0.27 | 0.79 | 0.98 | - |
| 22/05/2022 | Away | Callum Wilson | Burnley FC | 60 | 0-1 → 0-2 | 0.16 | 0.68 | 0.85 | Allan Saint-Maximin |