| 22/08/2021 | Home | Fred (OG) | Manchester United FC | 30 | 0-0 → 1-0 | 0.29 | - | - | - |
| 28/08/2021 | Away | Mohamed Elyounoussi | Newcastle United FC | 74 | 1-0 → 1-1 | 0.31 | 0.86 | 0.99 | - |
| 28/08/2021 | Away | James Ward-Prowse | Newcastle United FC | 96 | 2-1 → 2-2 | 0.33 | 0.79 | 1.00 | - |
| 02/10/2021 | Away | James Ward-Prowse | Chelsea FC | 61 | 1-0 → 1-1 | 0.30 | 0.79 | 0.99 | - |
| 16/10/2021 | Home | Armando Broja | Leeds United FC | 53 | 0-0 → 1-0 | 0.35 | 0.30 | 0.74 | Nathan Redmond |
| 23/10/2021 | Home | Valentino Livramento | Burnley FC | 41 | 0-1 → 1-1 | 0.25 | 0.16 | 0.21 | Nathan Redmond |
| 23/10/2021 | Home | Armando Broja | Burnley FC | 50 | 1-1 → 2-1 | 0.35 | 0.06 | 0.51 | Ibrahima Diallo |
| 30/10/2021 | Away | Che Adams | Watford FC | 20 | 0-0 → 0-1 | 0.27 | 0.07 | 0.60 | Adam Armstrong |
| 05/11/2021 | Home | Adam Armstrong | Aston Villa FC | 3 | 0-0 → 1-0 | 0.23 | 0.04 | 0.19 | - |
| 20/11/2021 | Away | Che Adams | Norwich City FC | 4 | 0-0 → 0-1 | 0.25 | 0.08 | 0.63 | Adam Armstrong |
| 01/12/2021 | Home | Jan Bednarek | Leicester City FC | 3 | 0-0 → 1-0 | 0.23 | 0.43 | 0.66 | - |
| 01/12/2021 | Home | Che Adams | Leicester City FC | 34 | 1-1 → 2-1 | 0.29 | 0.21 | 0.38 | Nathan Redmond |
| 04/12/2021 | Home | Armando Broja | Brighton & Hove Albion FC | 29 | 0-0 → 1-0 | 0.30 | 0.58 | 0.85 | Nathan Redmond |
| 15/12/2021 | Away | James Ward-Prowse | Crystal Palace FC | 32 | 1-0 → 1-1 | 0.27 | 0.06 | 0.32 | - |
| 15/12/2021 | Away | Armando Broja | Crystal Palace FC | 36 | 1-1 → 1-2 | 0.29 | 0.03 | 0.12 | Kyle Walker-Peters |
| 26/12/2021 | Away | Mohamed Elyounoussi | West Ham United FC | 8 | 0-0 → 0-1 | 0.26 | 0.08 | 0.14 | Kyle Walker-Peters |
| 26/12/2021 | Away | James Ward-Prowse | West Ham United FC | 61 | 1-1 → 1-2 | 0.37 | 0.79 | 0.98 | - |
| 26/12/2021 | Away | Jan Bednarek | West Ham United FC | 70 | 2-2 → 2-3 | 0.42 | 0.05 | 0.36 | James Ward-Prowse |
| 28/12/2021 | Home | James Ward-Prowse | Tottenham Hotspur FC | 25 | 0-0 → 1-0 | 0.27 | 0.02 | 0.45 | - |
| 11/01/2022 | Home | Jan Bednarek | Brentford FC | 5 | 0-0 → 1-0 | 0.26 | 0.20 | 0.08 | James Ward-Prowse |
| 11/01/2022 | Home | Álvaro Fernández (OG) | Brentford FC | 37 | 1-1 → 2-1 | 0.30 | - | - | - |
| 11/01/2022 | Home | Armando Broja | Brentford FC | 49 | 2-1 → 3-1 | 0.16 | 0.64 | 0.96 | Oriol Romeu |
| 11/01/2022 | Home | Che Adams | Brentford FC | 70 | 3-1 → 4-1 | 0.03 | 0.22 | 0.24 | Ibrahima Diallo |
| 15/01/2022 | Away | James Ward-Prowse | Wolverhampton Wanderers FC | 84 | 2-0 → 2-1 | 0.05 | 0.03 | 0.59 | - |
| 22/01/2022 | Home | Kyle Walker-Peters | Manchester City FC | 7 | 0-0 → 1-0 | 0.25 | 0.08 | 0.46 | Nathan Redmond |
| 09/02/2022 | Away | Armando Broja | Tottenham Hotspur FC | 23 | 1-0 → 1-1 | 0.23 | 0.27 | 0.72 | Romain Perraud |
| 09/02/2022 | Away | Mohamed Elyounoussi | Tottenham Hotspur FC | 79 | 2-1 → 2-2 | 0.34 | 0.08 | 0.15 | James Ward-Prowse |
| 09/02/2022 | Away | Che Adams | Tottenham Hotspur FC | 82 | 2-2 → 2-3 | 0.52 | 0.08 | 0.34 | James Ward-Prowse |
| 12/02/2022 | Away | Che Adams | Manchester United FC | 48 | 1-0 → 1-1 | 0.26 | 0.09 | 0.11 | Mohamed Elyounoussi |
| 19/02/2022 | Home | Stuart Armstrong | Everton FC | 52 | 0-0 → 1-0 | 0.35 | 0.06 | 0.24 | Che Adams |
| 19/02/2022 | Home | Shane Long | Everton FC | 84 | 1-0 → 2-0 | 0.07 | 0.14 | 0.85 | Valentino Livramento |
| 25/02/2022 | Home | Che Adams | Norwich City FC | 36 | 0-0 → 1-0 | 0.29 | 0.54 | 0.99 | - |
| 25/02/2022 | Home | Oriol Romeu | Norwich City FC | 88 | 1-0 → 2-0 | 0.04 | 0.03 | 0.11 | - |
| 10/03/2022 | Home | Stuart Armstrong | Newcastle United FC | 25 | 0-0 → 1-0 | 0.27 | 0.33 | 0.89 | - |
| 13/03/2022 | Home | Mohamed Elyounoussi | Watford FC | 45 | 0-2 → 1-2 | 0.14 | 0.39 | 0.92 | Che Adams |
| 02/04/2022 | Away | James Ward-Prowse | Leeds United FC | 49 | 1-0 → 1-1 | 0.26 | 0.07 | 0.44 | - |
| 16/04/2022 | Home | Jan Bednarek | Arsenal FC | 44 | 0-0 → 1-0 | 0.31 | 0.11 | 0.28 | Mohamed Elyounoussi |
| 24/04/2022 | Away | James Ward-Prowse | Brighton & Hove Albion FC | 49 | 2-0 → 2-1 | 0.14 | 0.08 | 0.26 | - |
| 24/04/2022 | Away | James Ward-Prowse | Brighton & Hove Albion FC | 54 | 2-1 → 2-2 | 0.28 | 0.04 | 0.37 | Oriol Romeu |
| 30/04/2022 | Home | Oriol Romeu | Crystal Palace FC | 9 | 0-0 → 1-0 | 0.27 | 0.15 | 0.21 | James Ward-Prowse |
| 17/05/2022 | Home | Nathan Redmond | Liverpool FC | 13 | 0-0 → 1-0 | 0.26 | 0.04 | 0.57 | Nathan Tella |
| 22/05/2022 | Away | James Ward-Prowse | Leicester City FC | 79 | 2-0 → 2-1 | 0.07 | 0.79 | 0.96 | - |