| 14/08/2021 | Home | Abdoulaye Doucouré | Southampton FC | 76 | 1-1 → 2-1 | 0.46 | 0.04 | 0.56 | Alex Iwobi |
| 14/08/2021 | Home | Dominic Calvert-Lewin | Southampton FC | 81 | 2-1 → 3-1 | 0.09 | 0.37 | 0.65 | Richarlison |
| 21/08/2021 | Away | Dominic Calvert-Lewin | Leeds United FC | 30 | 0-0 → 0-1 | 0.29 | 0.79 | 0.99 | - |
| 21/08/2021 | Away | Demarai Gray | Leeds United FC | 50 | 1-1 → 1-2 | 0.35 | 0.07 | 0.59 | Abdoulaye Doucouré |
| 28/08/2021 | Away | Demarai Gray | Brighton & Hove Albion FC | 41 | 0-0 → 0-1 | 0.32 | 0.04 | 0.23 | Allan |
| 28/08/2021 | Away | Dominic Calvert-Lewin | Brighton & Hove Albion FC | 58 | 0-1 → 0-2 | 0.16 | 0.79 | 0.99 | - |
| 13/09/2021 | Home | Michael Keane | Burnley FC | 60 | 0-1 → 1-1 | 0.29 | 0.25 | 0.31 | Andros Townsend |
| 13/09/2021 | Home | Andros Townsend | Burnley FC | 65 | 1-1 → 2-1 | 0.41 | 0.02 | 0.54 | Abdoulaye Doucouré |
| 13/09/2021 | Home | Demarai Gray | Burnley FC | 66 | 2-1 → 3-1 | 0.14 | 0.55 | 0.64 | Abdoulaye Doucouré |
| 25/09/2021 | Home | Andros Townsend | Norwich City FC | 29 | 0-0 → 1-0 | 0.30 | 0.79 | 0.94 | - |
| 25/09/2021 | Home | Abdoulaye Doucouré | Norwich City FC | 77 | 1-0 → 2-0 | 0.11 | 0.14 | 0.39 | Demarai Gray |
| 02/10/2021 | Away | Andros Townsend | Manchester United FC | 65 | 1-0 → 1-1 | 0.28 | 0.46 | 0.81 | Abdoulaye Doucouré |
| 23/10/2021 | Home | Tom Davies | Watford FC | 3 | 0-0 → 1-0 | 0.23 | 0.41 | 0.98 | Demarai Gray |
| 23/10/2021 | Home | Richarlison | Watford FC | 63 | 1-1 → 2-1 | 0.38 | 0.33 | 0.16 | Michael Keane |
| 01/11/2021 | Away | Alex Iwobi | Wolverhampton Wanderers FC | 66 | 2-0 → 2-1 | 0.11 | 0.17 | 0.07 | Michael Keane |
| 01/12/2021 | Home | Demarai Gray | Liverpool FC | 38 | 0-2 → 1-2 | 0.08 | 0.34 | 0.07 | Richarlison |
| 06/12/2021 | Home | Richarlison | Arsenal FC | 80 | 0-1 → 1-1 | 0.34 | 0.33 | 0.62 | - |
| 06/12/2021 | Home | Demarai Gray | Arsenal FC | 92 | 1-1 → 2-1 | 0.63 | 0.03 | 0.33 | André Gomes |
| 12/12/2021 | Away | Salomón Rondón | Crystal Palace FC | 70 | 2-0 → 2-1 | 0.09 | 0.27 | 0.98 | - |
| 16/12/2021 | Away | Jarrad Branthwaite | Chelsea FC | 74 | 1-0 → 1-1 | 0.31 | 0.47 | 0.82 | Anthony Gordon |
| 02/01/2022 | Home | Anthony Gordon | Brighton & Hove Albion FC | 53 | 0-2 → 1-2 | 0.12 | 0.02 | 0.08 | Allan |
| 02/01/2022 | Home | Anthony Gordon | Brighton & Hove Albion FC | 76 | 1-3 → 2-3 | 0.08 | 0.09 | 0.33 | Jonjoe Kenny |
| 15/01/2022 | Away | Richarlison | Norwich City FC | 60 | 2-0 → 2-1 | 0.12 | 0.07 | 0.16 | - |
| 08/02/2022 | Away | Jamaal Lascelles (OG) | Newcastle United FC | 36 | 0-0 → 0-1 | 0.29 | - | - | - |
| 12/02/2022 | Home | Séamus Coleman | Leeds United FC | 10 | 0-0 → 1-0 | 0.26 | 0.88 | 0.97 | - |
| 12/02/2022 | Home | Michael Keane | Leeds United FC | 23 | 1-0 → 2-0 | 0.18 | 0.13 | 0.52 | Anthony Gordon |
| 12/02/2022 | Home | Anthony Gordon | Leeds United FC | 78 | 2-0 → 3-0 | 0.01 | 0.20 | 0.51 | Richarlison |
| 17/03/2022 | Home | Alex Iwobi | Newcastle United FC | 99 | 0-0 → 1-0 | 0.65 | 0.23 | 0.40 | Dominic Calvert-Lewin |
| 03/04/2022 | Away | Mason Holgate | West Ham United FC | 53 | 1-0 → 1-1 | 0.28 | 0.04 | 0.40 | Richarlison |
| 06/04/2022 | Away | Richarlison | Burnley FC | 18 | 1-0 → 1-1 | 0.24 | 0.79 | 0.99 | - |
| 06/04/2022 | Away | Richarlison | Burnley FC | 41 | 1-1 → 1-2 | 0.32 | 0.79 | 0.97 | - |
| 09/04/2022 | Home | Anthony Gordon | Manchester United FC | 27 | 0-0 → 1-0 | 0.27 | 0.04 | 0.05 | - |
| 20/04/2022 | Home | Richarlison | Leicester City FC | 92 | 0-1 → 1-1 | 0.33 | 0.11 | 0.49 | Salomón Rondón |
| 01/05/2022 | Home | Richarlison | Chelsea FC | 46 | 0-0 → 1-0 | 0.32 | 0.28 | 0.69 | Demarai Gray |
| 08/05/2022 | Away | Vitaliy Mykolenko | Leicester City FC | 6 | 0-0 → 0-1 | 0.25 | 0.05 | 0.41 | Alex Iwobi |
| 08/05/2022 | Away | Mason Holgate | Leicester City FC | 30 | 1-1 → 1-2 | 0.29 | 0.29 | 0.23 | - |
| 15/05/2022 | Home | Dominic Calvert-Lewin | Brentford FC | 10 | 0-0 → 1-0 | 0.26 | 0.56 | 0.98 | Richarlison |
| 15/05/2022 | Home | Richarlison | Brentford FC | 47 | 1-1 → 2-1 | 0.32 | 0.79 | 0.95 | - |
| 19/05/2022 | Home | Michael Keane | Crystal Palace FC | 54 | 0-2 → 1-2 | 0.11 | 0.05 | 0.22 | Mason Holgate |
| 19/05/2022 | Home | Richarlison | Crystal Palace FC | 75 | 1-2 → 2-2 | 0.32 | 0.08 | 0.52 | - |
| 19/05/2022 | Home | Dominic Calvert-Lewin | Crystal Palace FC | 85 | 2-2 → 3-2 | 0.56 | 0.15 | 0.32 | Demarai Gray |
| 22/05/2022 | Away | Donny van de Beek | Arsenal FC | 48 | 2-0 → 2-1 | 0.13 | 0.91 | 0.92 | Dominic Calvert-Lewin |