| 20/09/2020 | Home | Danny Ings | Tottenham Hotspur FC | 90 | 1-5 → 2-5 | 0.00 | 0.79 | 0.88 | - |
| 26/09/2020 | Away | Danny Ings | Burnley FC | 5 | 0-0 → 0-1 | 0.26 | 0.39 | 0.70 | Che Adams |
| 04/10/2020 | Home | Moussa Djenepo | West Bromwich Albion FC | 41 | 0-0 → 1-0 | 0.32 | 0.06 | 0.16 | - |
| 04/10/2020 | Home | Oriol Romeu | West Bromwich Albion FC | 69 | 1-0 → 2-0 | 0.13 | 0.06 | 0.23 | Stuart Armstrong |
| 17/10/2020 | Away | Danny Ings | Chelsea FC | 43 | 2-0 → 2-1 | 0.15 | 0.70 | 0.92 | Che Adams |
| 17/10/2020 | Away | Che Adams | Chelsea FC | 57 | 2-1 → 2-2 | 0.29 | 0.66 | 0.95 | - |
| 17/10/2020 | Away | Jannik Vestergaard | Chelsea FC | 92 | 3-2 → 3-3 | 0.33 | 0.09 | 0.49 | Theo Walcott |
| 25/10/2020 | Home | James Ward-Prowse | Everton FC | 27 | 0-0 → 1-0 | 0.27 | 0.07 | 0.17 | Danny Ings |
| 25/10/2020 | Home | Che Adams | Everton FC | 35 | 1-0 → 2-0 | 0.18 | 0.06 | 0.11 | Danny Ings |
| 01/11/2020 | Away | Jannik Vestergaard | Aston Villa FC | 20 | 0-0 → 0-1 | 0.27 | 0.14 | 0.73 | James Ward-Prowse |
| 01/11/2020 | Away | James Ward-Prowse | Aston Villa FC | 33 | 0-1 → 0-2 | 0.17 | 0.09 | 0.32 | - |
| 01/11/2020 | Away | James Ward-Prowse | Aston Villa FC | 45 | 0-2 → 0-3 | 0.06 | 0.14 | 0.62 | - |
| 01/11/2020 | Away | Danny Ings | Aston Villa FC | 58 | 0-3 → 0-4 | 0.01 | 0.03 | 0.58 | Stuart Armstrong |
| 06/11/2020 | Home | Che Adams | Newcastle United FC | 7 | 0-0 → 1-0 | 0.25 | 0.08 | 0.09 | Theo Walcott |
| 06/11/2020 | Home | Stuart Armstrong | Newcastle United FC | 82 | 1-0 → 2-0 | 0.09 | 0.06 | 0.22 | - |
| 23/11/2020 | Away | Theo Walcott | Wolverhampton Wanderers FC | 58 | 0-0 → 0-1 | 0.36 | 0.38 | 0.50 | Che Adams |
| 29/11/2020 | Home | Jan Bednarek | Manchester United FC | 23 | 0-0 → 1-0 | 0.27 | 0.09 | 0.04 | James Ward-Prowse |
| 29/11/2020 | Home | James Ward-Prowse | Manchester United FC | 33 | 1-0 → 2-0 | 0.17 | 0.08 | 0.33 | - |
| 07/12/2020 | Away | Jannik Vestergaard | Brighton & Hove Albion FC | 45 | 1-0 → 1-1 | 0.27 | 0.05 | 0.37 | James Ward-Prowse |
| 07/12/2020 | Away | Danny Ings | Brighton & Hove Albion FC | 81 | 1-1 → 1-2 | 0.50 | 0.79 | 0.99 | - |
| 13/12/2020 | Home | Che Adams | Sheffield United FC | 34 | 0-0 → 1-0 | 0.29 | 0.36 | 0.63 | Jan Bednarek |
| 13/12/2020 | Home | Stuart Armstrong | Sheffield United FC | 62 | 1-0 → 2-0 | 0.16 | 0.04 | 0.15 | Danny Ings |
| 13/12/2020 | Home | Nathan Redmond | Sheffield United FC | 83 | 2-0 → 3-0 | 0.01 | 0.24 | 0.83 | Oriol Romeu |
| 16/12/2020 | Away | Theo Walcott | Arsenal FC | 18 | 0-0 → 0-1 | 0.26 | 0.31 | 0.11 | Che Adams |
| 04/01/2021 | Home | Danny Ings | Liverpool FC | 2 | 0-0 → 1-0 | 0.28 | 0.08 | 0.81 | James Ward-Prowse |
| 26/01/2021 | Home | Stuart Armstrong | Arsenal FC | 3 | 0-0 → 1-0 | 0.23 | 0.05 | 0.16 | James Ward-Prowse |
| 06/02/2021 | Away | Takumi Minamino | Newcastle United FC | 30 | 2-0 → 2-1 | 0.12 | 0.05 | 0.11 | Ryan Bertrand |
| 06/02/2021 | Away | James Ward-Prowse | Newcastle United FC | 48 | 3-1 → 3-2 | 0.13 | 0.06 | 0.51 | - |
| 14/02/2021 | Home | Danny Ings | Wolverhampton Wanderers FC | 25 | 0-0 → 1-0 | 0.27 | 0.29 | 0.64 | Stuart Armstrong |
| 20/02/2021 | Home | Takumi Minamino | Chelsea FC | 33 | 0-0 → 1-0 | 0.30 | 0.39 | 0.47 | Nathan Redmond |
| 06/03/2021 | Away | James Ward-Prowse | Sheffield United FC | 32 | 0-0 → 0-1 | 0.30 | 0.79 | 0.98 | - |
| 06/03/2021 | Away | Che Adams | Sheffield United FC | 49 | 0-1 → 0-2 | 0.16 | 0.05 | 0.19 | Stuart Armstrong |
| 10/03/2021 | Away | James Ward-Prowse | Manchester City FC | 25 | 1-0 → 1-1 | 0.22 | 0.79 | 0.85 | - |
| 10/03/2021 | Away | Che Adams | Manchester City FC | 56 | 4-1 → 4-2 | 0.02 | 0.51 | 0.84 | - |
| 14/03/2021 | Home | Che Adams | Brighton & Hove Albion FC | 27 | 0-1 → 1-1 | 0.25 | 0.14 | 0.36 | - |
| 04/04/2021 | Home | Stuart Armstrong | Burnley FC | 31 | 0-2 → 1-2 | 0.14 | 0.06 | 0.05 | Danny Ings |
| 04/04/2021 | Home | Danny Ings | Burnley FC | 42 | 1-2 → 2-2 | 0.26 | 0.51 | 0.53 | Nathan Redmond |
| 04/04/2021 | Home | Nathan Redmond | Burnley FC | 66 | 2-2 → 3-2 | 0.40 | 0.10 | 0.06 | Theo Walcott |
| 21/04/2021 | Away | Danny Ings | Tottenham Hotspur FC | 30 | 0-0 → 0-1 | 0.29 | 0.08 | 0.57 | James Ward-Prowse |
| 30/04/2021 | Home | James Ward-Prowse | Leicester City FC | 61 | 0-0 → 1-0 | 0.37 | 0.79 | 0.99 | - |
| 11/05/2021 | Home | Danny Ings | Crystal Palace FC | 19 | 0-1 → 1-1 | 0.24 | 0.07 | 0.42 | Nathan Redmond |
| 11/05/2021 | Home | Che Adams | Crystal Palace FC | 48 | 1-1 → 2-1 | 0.33 | 0.26 | 0.20 | Stuart Armstrong |
| 11/05/2021 | Home | Danny Ings | Crystal Palace FC | 75 | 2-1 → 3-1 | 0.11 | 0.46 | 0.96 | Che Adams |
| 15/05/2021 | Home | Che Adams | Fulham FC | 27 | 0-0 → 1-0 | 0.27 | 0.59 | 0.85 | James Ward-Prowse |
| 15/05/2021 | Home | Nathan Tella | Fulham FC | 60 | 1-0 → 2-0 | 0.16 | 0.41 | 0.53 | Kyle Walker-Peters |
| 15/05/2021 | Home | Theo Walcott | Fulham FC | 82 | 2-1 → 3-1 | 0.09 | 0.06 | 0.12 | Nathan Tella |